INT165483

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.65
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD63) plasma membrane (CD63)
Anatomy Link Frequency
basophils 4
leukocyte 2
CD63 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 96.52 Very High Very High Very High
Inflammation 23 96.12 Very High Very High Very High
Multiple sclerosis 6 93.00 High High
Restless leg syndrome 2 80.28 Quite High
Pain 1 69.04 Quite High
Kinase C 34 59.36 Quite High
local anesthetic 2 50.00 Quite Low
agonist 14 5.60 Low Low
depression 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 98.52 Very High Very High Very High
INFLAMMATION 23 96.12 Very High Very High Very High
Disease Progression 1 94.92 High High
Demyelinating Disease 7 93.00 High High
Encephalitis 1 92.48 High High
Amputation 1 87.92 High High
Peripheral Arterial Disease 5 86.24 High High
Paralysis 1 80.88 Quite High
Increased Venous Pressure Under Development 8 80.28 Quite High
Pain 1 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quercetin showed also a marked ability to decrease in a dose-dependent fashion the expression of CD63 in basophils activated with the calcium ionophore A23187 (Figure 2, panels A,B).
Negative_regulation (decrease) of Gene_expression (expression) of CD63 in basophils
1) Confidence 0.49 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.03
In basophils stimulated with anti-human IgE, quercetin was able to inhibit in a dose-dependent fashion both the tetraspan (Figure 1, panels A,B) and the ectoenzyme up-regulation (Figure 1 panel C); quercetin IC50 able to inhibit CD63 expression was about 0.132 ?
Negative_regulation (inhibit) of Gene_expression (expression) of CD63 in basophils
2) Confidence 0.36 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0
Novel aspects of the morphological analysis include reduced LC3 labelling of the large vacuoles in cells treated with 3-methyl-adenine, inhibition of CD63 labelling of these vacuoles by co-expression of dominant negative Rab7, retention of secretory green fluorescent protein (GFP) possessing a signal sequence in vacuolar cells, and partial vacuole labelling with lysosomal-associated membrane protein 1 (LAMP1).
Negative_regulation (inhibition) of Gene_expression (labelling) of CD63
3) Confidence 0.08 Published 2010 Journal Can J Anaesth Section Body Doc Link 20054683 Disease Relevance 0.07 Pain Relevance 0
Lovastatin treatment also attenuated the transmigration of mononuclear cells by downregulating the expression of leukocyte function antigen-1 (LFA-1), a ligand for intercellular adhesion molecule (ICAM), in endothelial-leukocyte interaction [88] and mononuclear cell infiltration into the CNS has been implicated in MS [89].
Negative_regulation (downregulating) of Gene_expression (expression) of antigen-1 in leukocyte associated with multiple sclerosis and adhesions
4) Confidence 0.01 Published 2005 Journal J Negat Results Biomed Section Body Doc Link PMC1079931 Disease Relevance 1.58 Pain Relevance 0.56

General Comments

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