INT165488

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.39
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar5) signal transducer activity (Lpar5)
Lpar5 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 91.44 High High
alcohol 4 89.76 High High
antagonist 30 83.48 Quite High
Neuropathic pain 18 41.84 Quite Low
Inflammation 4 37.44 Quite Low
fibrosis 20 36.32 Quite Low
Potency 6 13.12 Low Low
dorsal root ganglion 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 32 74.56 Quite High
Metastasis 20 68.40 Quite High
Cancer 50 67.96 Quite High
Disease 16 45.84 Quite Low
Neuropathic Pain 22 41.84 Quite Low
Reprotox - General 3 2 40.40 Quite Low
Ovarian Cancer 32 5.00 Very Low Very Low Very Low
Apoptosis 30 5.00 Very Low Very Low Very Low
Fibrosis 14 5.00 Very Low Very Low Very Low
Infection 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite this controversy, farnesyl mono- and diphosphate are important pharmacological tools that allow for the selective activation of LPA5 (?
Positive_regulation (activation) of LPA5
1) Confidence 0.35 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.11 Pain Relevance 0.21
(Oh da et al., 2008) reported that farnesyl monophosphate and arachidonoyl glycerol were more potent activators of LPA5 than LPA.
Positive_regulation (activators) of LPA5
2) Confidence 0.25 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.14 Pain Relevance 0.27
They are encoded by distinct genes named LPAR1-LPAR5 in humans and Lpar1-Lpar5 in mice.
Positive_regulation (named) of LPAR1-LPAR5
3) Confidence 0.22 Published 2010 Journal Annu. Rev. Pharmacol. Toxicol. Section Abstract Doc Link 20055701 Disease Relevance 0.07 Pain Relevance 0
They are encoded by distinct genes named LPAR1-LPAR5 in humans and Lpar1-Lpar5 in mice.
Positive_regulation (named) of Lpar1-Lpar5
4) Confidence 0.22 Published 2010 Journal Annu. Rev. Pharmacol. Toxicol. Section Abstract Doc Link 20055701 Disease Relevance 0.07 Pain Relevance 0

General Comments

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