INT165516

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.41
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MSX2) transcription factor binding (MSX2) cytoplasm (MSX2)
Anatomy Link Frequency
foot 4
body segments 1
PFM 1
MSX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 100.00 Very High Very High Very High
vaginimus 3 10.00 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 2 100.00 Very High Very High Very High
Heterotopic Ossification 174 99.16 Very High Very High Very High
Endometrial Cancer 153 98.04 Very High Very High Very High
Stress Fractures 20 86.24 High High
Apoptosis 16 77.88 Quite High
Targeted Disruption 24 76.60 Quite High
Congenital Anomalies 10 70.92 Quite High
Fibrodysplasia Ossificans Progressiva 34 68.00 Quite High
Disease 9 64.16 Quite High
Aneuploidy 3 61.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Posttreatment improvements included less PFM responsiveness to pain, less PFM tone, improved vaginal flexibility, and improved PFM relaxation capacity, such that women with PVD no longer differed from controls on these measures.
Regulation (responsiveness) of PFM in PFM
1) Confidence 0.23 Published 2010 Journal J Sex Med Section Body Doc Link 20059663 Disease Relevance 0 Pain Relevance 0
Intestinal trefoil protein, TFF3, AGR2 developmental gene, estrogen-regulated genes (MGB2, LTF, END1, MMP11), FOXA2, and MSX2 were significantly up-regulated in endometrioid endometrial carcinomas, while increased expression of FOLR, genes involved in the regulation of mitotic spindle checkpoint (STK15, BUB1, CCNB2), IGF2, PTGS1 and p16 were seen in non-endometrioid endometrial carcinomas.
Regulation (regulated) of MSX2 associated with endometrial cancer
2) Confidence 0.19 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.25 Pain Relevance 0
Results of the ANOVAs performed on selected FM variables (table 2) reveal that PFM and IMP were significantly affected by foot rotation condition.
Regulation (affected) of PFM in foot
3) Confidence 0.11 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0 Pain Relevance 0
Second, r was calculated between the relative change in foot rotation angle in the INT and EXT foot rotation conditions and the corresponding change in PFM and IMP with respect to normal walking.
Regulation (change) of PFM in foot
4) Confidence 0.11 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0 Pain Relevance 0
However, it is interesting to note that changes in either absolute or relative PFM and IMP were not particularly dependent on the absolute or relative foot rotation angle adopted during stance.
Regulation (changes) of PFM in foot
5) Confidence 0.11 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0.07 Pain Relevance 0
Given that we standardized arm swing within subject and across conditions, the greater PFM values observed for some participants in the EXT condition suggests the existence of transverse plane movement modifications employed by other body segments.
Regulation (values) of PFM in body segments
6) Confidence 0.11 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0.09 Pain Relevance 0
This was done in two ways: first, r was calculated between the 'absolute' foot rotation angle in each condition and the corresponding PFM and IMP values obtained.
Regulation (values) of PFM in foot
7) Confidence 0.11 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0 Pain Relevance 0
In fact, overexpression of MSX2, a BMP target gene, can induce an HO-like phenotype.
Regulation (target) of MSX2 associated with heterotopic ossification
8) Confidence 0.09 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.93 Pain Relevance 0.04
MSX2 overexpression elicited the phenotype under control of either an ubiquitous promoter, such as CMV, a tissue specific promoter, such as TIMPl (tissue inhibitor of metalloproteinase 1), or the endogenous MSX2 promoter [35, 62].
Regulation (control) of MSX2 associated with metalloproteinase and cytomegalovirus infection
9) Confidence 0.09 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 1.07 Pain Relevance 0.05

General Comments

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