INT165537

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.55
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp7) anatomical structure formation involved in morphogenesis (Bmp7) extracellular space (Bmp7)
growth (Bmp7) extracellular region (Bmp7)
Anatomy Link Frequency
eye 1
kidney 1
Bmp7 (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 5 99.84 Very High Very High Very High
cINOD 5 96.88 Very High Very High Very High
imagery 1 70.00 Quite High
COX2 1 25.00 Low Low
bDMF 98 5.00 Very Low Very Low Very Low
Nerve growth factor 12 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fracture Healing 6 100.00 Very High Very High Very High
Osteoporosis 1 96.88 Very High Very High Very High
INFLAMMATION 1 49.24 Quite Low
Ganglion Cysts 88 42.36 Quite Low
Apoptosis 6 28.12 Quite Low
Death 14 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data demonstrate that the bone anabolic effect of BMP-7 and fracture healing is impaired by diclofenac application, and suggest that the potential negative impact of NSAIDs on fracture healing is, at least in part, due to interference with BMP-7 signaling.
Negative_regulation (impaired) of BMP-7 associated with fracture healing, cinod and diclofenac
1) Confidence 0.43 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20063306 Disease Relevance 0.55 Pain Relevance 0.52
Interestingly, removal of functional BMP7 in mice causes deficits that are restricted to the developing eye and kidney [14,15].
Negative_regulation (removal) of BMP7 in kidney
2) Confidence 0.28 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0
Interestingly, removal of functional BMP7 in mice causes deficits that are restricted to the developing eye and kidney [14,15].
Negative_regulation (removal) of BMP7 in eye
3) Confidence 0.10 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0

General Comments

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