INT165538

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.87
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp7) anatomical structure formation involved in morphogenesis (Bmp7) extracellular space (Bmp7)
growth (Bmp7) extracellular region (Bmp7)
Anatomy Link Frequency
hamstring muscles 1
bursa 1
epibranchial placode 1
Bmp7 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 36 100.00 Very High Very High Very High
Central nervous system 22 98.88 Very High Very High Very High
diclofenac 10 97.00 Very High Very High Very High
cytokine 18 94.28 High High
Inflammation 84 93.88 High High
imagery 3 92.56 High High
antagonist 11 83.68 Quite High
Inflammatory response 10 34.16 Quite Low
COX2 2 25.00 Low Low
fibrosis 1 24.88 Low Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 128 98.12 Very High Very High Very High
Fracture Healing 12 96.88 Very High Very High Very High
INFLAMMATION 100 93.88 High High
Gliosis 23 90.16 High High
Osteoporosis 2 63.92 Quite High
Necrosis 5 47.12 Quite Low
Cancer 9 46.76 Quite Low
Ganglion Cysts 44 31.72 Quite Low
Fibrosis 1 24.88 Low Low
Apoptosis 3 17.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To experimentally address the possible interaction between BMP-7 and COX-2, we then induced ectopic bone formation in control (n = 10) and diclofenac-treated mice (n = 10) by application of BMP-7 (recombinant human OP-1, rhOP-1) into the hamstring muscles.
BMP-7 Binding (interaction) of in hamstring muscles associated with diclofenac
1) Confidence 0.37 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20063306 Disease Relevance 0.52 Pain Relevance 0.55
The aim of the present study was to determine if the impairment of bone healing by systemic NSAID application is, at least in part, due to an interaction of NSAIDs with the bone anabolic BMP-7 pathway.
BMP-7 Binding (interaction) of associated with cinod
2) Confidence 0.31 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20063306 Disease Relevance 0.45 Pain Relevance 0.53
Therefore, it is possible that BMP7 is not important for epibranchial placode formation in mice or more likely, that another BMP family member functions redundantly with BMP7 to induce epibranchial placode formation [15,16].
BMP7 Binding (redundantly) of in epibranchial placode
3) Confidence 0.25 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0
superfamily ligands such as BMP1, BMP2, BMP5, and BMP7 were also expressed in the CNS after KA-induced neurodegeneration (supporting information Table 1).
BMP7 Binding (ligands) of associated with central nervous system
4) Confidence 0.16 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.91 Pain Relevance 0.31
U AP/100 mg of bursa tissue (P = 0.0021) and 50 ng/ml of recombinant BMP-7 induced 430 ± 111 ?
BMP-7 Binding (recombinant) of in bursa
5) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0 Pain Relevance 0

General Comments

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