INT165578

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
dorsal horn 2
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 118 100.00 Very High Very High Very High
nMDA receptor 49 100.00 Very High Very High Very High
Dorsal horn 3 99.80 Very High Very High Very High
spinal dorsal horn 1 93.60 High High
Glutamate 6 82.64 Quite High
intrathecal 1 74.72 Quite High
depression 44 71.36 Quite High
gABA 1 52.80 Quite High
antagonist 19 50.80 Quite High
Pyramidal cell 7 35.92 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 47 95.24 Very High Very High Very High
Stress Incontinence 3 90.32 High High
Injury 2 77.84 Quite High
Death 3 77.04 Quite High
Depression 44 71.36 Quite High
INFLAMMATION 7 24.32 Low Low
Cancer 2 21.28 Low Low
Necrosis 2 20.80 Low Low
Drug Induced Neurotoxicity 8 5.00 Very Low Very Low Very Low
Kernicterus 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that the importance of NR2B-NMDARs for LTP induction is protocol-dependent, we attempted to know whether the role of NR2B-NMDARs in memory acquisition is also dependent on training paradigms.
Regulation (dependent) of Positive_regulation (importance) of NR2B-NMDARs associated with long-term potentiation
1) Confidence 0.41 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.58 Pain Relevance 0.08
Real-time polymerase chain reaction analysis showed that the mRNA expression profiles for NR1, NR2A, and NR2B subunits were not significantly changed by 10 ┬ÁM UCB treatment for 48 h (p<0.05) (Figure 5).
Neg (not) Regulation (changed) of Positive_regulation (profiles) of NR2B
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.23 Pain Relevance 0.40
When compared with vehicle solution, intracolonic mustard oil sensitized the NMDA receptor NR2B subunit-dependent reflex activity and increased expression levels of phosphorylated Akt (pAkt) and phosphorylated NR2B (pNR2B) in dorsal horn.
Regulation (sensitized) of Positive_regulation (increased) of pNR2B in dorsal horn associated with nmda receptor and dorsal horn
3) Confidence 0.03 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20067569 Disease Relevance 0.25 Pain Relevance 0.26

General Comments

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