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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.81
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf, Ngf) signal transduction (Ngf) extracellular space (Ngf)
cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
neurons 2
Bdnf (Mus musculus)
Ngf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 5 100.00 Very High Very High Very High
hypoalgesia 1 96.68 Very High Very High Very High
nociceptor 6 88.76 High High
Pain 2 78.16 Quite High
Central nervous system 19 57.20 Quite High
depression 75 50.00 Quite Low
long-term potentiation 2 27.28 Quite Low
Hippocampus 53 10.80 Low Low
antidepressant 62 5.00 Very Low Very Low Very Low
Kinase C 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 4 100.00 Very High Very High Very High
Hypoalagesia 1 96.68 Very High Very High Very High
Heart Rate Under Development 5 89.44 High High
Congenital Anomalies 15 80.52 Quite High
Pain 2 78.16 Quite High
Dilated Cardiomyopathy 1 64.56 Quite High
Death 11 62.40 Quite High
Hyperplasia 2 51.68 Quite High
Depression 97 50.00 Quite Low
Dementia 15 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our in vitro analyses indicate that BDNF-dependent nociceptive neurons also respond to NGF and GDNF.
BDNF Binding (respond) of NGF in neurons associated with nociception
1) Confidence 0.33 Published 2010 Journal Dev. Biol. Section Abstract Doc Link 20067784 Disease Relevance 0.47 Pain Relevance 0.49
The interaction of neurotrophins with the Trk receptors is specific: NGF binds with TrkA, BDNF and NT 4 both bind with TrkB, and NT 3 binds with the highest affinity to TrkC but is also capable of signaling through TrkA and TrkB.
BDNF Binding (binds) of NGF associated with nerve growth factor
2) Confidence 0.18 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.13 Pain Relevance 0.20
Thus, strategies to interfere with NGF-mediated TRKA activation and BDNF-mediated p75NTR activation may prove beneficial in reducing sympathetic neuron sprouting and norepinephrine release [195-197].
BDNF Binding (interfere) of NGF in neuron
3) Confidence 0.12 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.22 Pain Relevance 0

General Comments

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