INT165589

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.54
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp11a1) oxidoreductase activity (Cyp11a1) lipid metabolic process (Cyp11a1)
Cyp11a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 16 99.40 Very High Very High Very High
Versed 1 87.76 High High
Analgesic 1 69.36 Quite High
headache 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 19 86.08 High High
Body Weight 2 84.12 Quite High
Stress 1 82.16 Quite High
Nephrotoxicity 5 81.68 Quite High
Apoptosis 1 52.40 Quite High
Infection 32 50.00 Quite Low
Hypersensitivity 3 45.04 Quite Low
Toxicity 2 39.48 Quite Low
Leukopenia 1 27.56 Quite Low
Vomiting 3 20.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, APAP administration significantly increased MDA, protein carbonylation, GSSG level, intracellular ROS production and cytochrome P450 enzyme (CYPP450) activity.
Positive_regulation (increased) of cytochrome P450 enzyme associated with paracetamol
1) Confidence 0.38 Published 2010 Journal Toxicology Section Abstract Doc Link 20067817 Disease Relevance 0.47 Pain Relevance 0.92
A review of 532 patients who had received dalbavancin during several clinical trials noted that 79% had received concomitant medications that possessed a potential for significant interaction through either inhibition or induction of the cytochrome P450 enzyme system (Buckwalter and Dowell 2005).
Positive_regulation (induction) of cytochrome P450 enzyme
2) Confidence 0.02 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503664 Disease Relevance 0.08 Pain Relevance 0.14

General Comments

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