INT165590

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.62
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a5) plasma membrane (Slc12a5) intracellular (Slc12a5)
transmembrane transport (Slc12a5)
Anatomy Link Frequency
Nerve 1
neurons 1
Slc12a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 26 99.20 Very High Very High Very High
bDMF 91 98.72 Very High Very High Very High
allodynia 84 95.84 Very High Very High Very High
Eae 46 94.96 High High
central sensitization 16 94.08 High High
Neuropathic pain 9 93.76 High High
Sciatic nerve 3 91.68 High High
Pain 30 89.76 High High
Lasting pain 1 87.56 High High
antinociception 2 85.04 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 99.50 Very High Very High Very High
INFLAMMATION 22 99.20 Very High Very High Very High
Neuropathic Pain 93 95.84 Very High Very High Very High
Stress 2 94.48 High High
Injury 56 93.28 High High
Pain 20 89.76 High High
Epilepsy 2 86.20 High High
Targeted Disruption 11 85.52 High High
Hyperalgesia 23 85.20 High High
Ganglion Cysts 8 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KCC2 mRNA was found to be down-regulated at 1d after pulpal inflammation, while NKCC1 was up-regulated.
Negative_regulation (regulated) of KCC2 mRNA associated with inflammation
1) Confidence 0.43 Published 2010 Journal Brain Res. Bull. Section Abstract Doc Link 20067823 Disease Relevance 0.35 Pain Relevance 0.49
KCC2 mRNA was found to be down-regulated at 1d after pulpal inflammation, while NKCC1 was up-regulated.
Negative_regulation (down) of KCC2 mRNA associated with inflammation
2) Confidence 0.43 Published 2010 Journal Brain Res. Bull. Section Abstract Doc Link 20067823 Disease Relevance 0.35 Pain Relevance 0.49
Inhibition of KCC2 by BUM would be expected to have the opposite effect on touch-evoked responses because decreased KCC2 expression (analogous to pharmacological inhibition) or KCC2 blockade with DIOA reverses the polarity of GABAAR responses in a subset of lamina I and II neurons, leading to allodynia which has been proposed as a mechanism of neuropathic pain [28].
Negative_regulation (blockade) of KCC2 in neurons associated with allodynia and neuropathic pain
3) Confidence 0.21 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.85 Pain Relevance 0.86
Nerve injury frequently results in a decrease of KCC2 messenger RNA (Nabekura et al., 2002).
Negative_regulation (decrease) of KCC2 in Nerve associated with nervous system injury
4) Confidence 0.17 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.54 Pain Relevance 0.20
This involves an alteration in the chloride equilibrium potential as a result of down regulation of the potassium-chloride exporter, KCC2.
Negative_regulation (regulation) of KCC2
5) Confidence 0.08 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2918544 Disease Relevance 0.54 Pain Relevance 0.93

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox