INT165597

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Context Info
Confidence 0.60
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.27
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
vesicles 1
Htt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 18 96.12 Very High Very High Very High
Glutamate 5 95.72 Very High Very High Very High
gABA 2 95.12 Very High Very High Very High
Neurotransmitter 3 93.48 High High
Substantia nigra 1 92.48 High High
Enkephalin 1 81.32 Quite High
Glutamate receptor 2 60.72 Quite High
projection neuron 4 57.96 Quite High
Hippocampus 4 53.80 Quite High
headache 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Disease 262 100.00 Very High Very High Very High
Toxicity 57 99.96 Very High Very High Very High
Death 13 98.80 Very High Very High Very High
Cognitive Disorder 15 96.00 Very High Very High Very High
Chorea 37 95.20 Very High Very High Very High
Dyskinesias 9 94.88 High High
Neurodegenerative Disease 29 92.96 High High
Huntington's Chorea 73 92.64 High High
Aging 164 92.00 High High
Headache 2 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
What defects might be involved in the age-dependent increase in mutant Htt toxicity?
Positive_regulation (increase) of mutant Htt associated with toxicity
1) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.98 Pain Relevance 0
In particular, Arrasate and collaborators [33] showed using video-microscopy analysis of striatal cells in culture that the accumulation of mutant Htt into large aggregates (“inclusion bodies”) correlates with improved survival.
Positive_regulation (accumulation) of mutant Htt
2) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.30 Pain Relevance 0
Only patients with HD-related headaches without previous history of primary headache were diagnosed as isolated HD headache (HDH).
Positive_regulation (isolated) of HDH
3) Confidence 0.50 Published 2009 Journal Arq Neuropsiquiatr Section Body Doc Link 20069204 Disease Relevance 0.08 Pain Relevance 0
Using the same method described for Ago2 (Fig. 3), the co-localizing puncta of Htt/mRNA/dynein were quantified (Fig. 6g).
Positive_regulation (puncta) of Htt
4) Confidence 0.48 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
We observed strong accumulation of mutant Htt –containing nuclear inclusions in young and old rats, suggesting that mutant Htt is expressed at relatively high levels.
Positive_regulation (accumulation) of mutant Htt
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.37 Pain Relevance 0.03
HD is caused by an expansion of CAG trinucleotide repeats in the HD gene that codes for huntingtin (Htt) [2].
Positive_regulation (caused) of HD associated with disease
6) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 1.04 Pain Relevance 0
Transcription of BDNF is reported deregulated in HD, and transport of BDNF secretory vesicles necessary for neuronal survival requires a functional Htt [7,8].
Positive_regulation (requires) of Htt in vesicles associated with disease
7) Confidence 0.39 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.69 Pain Relevance 0.03
It is not known if the accumulation of htt conglomerate results in cell death, or if the soluble form of the protein is the toxic form.8,9 Dopamine, glutamate, and GABA are thought to be the most involved neurotransmitters in HD and are targeted for treatment (Table 1).10–23
Positive_regulation (accumulation) of htt associated with neurotransmitter, gaba, glutamate, dopamine, huntington's chorea and death
8) Confidence 0.34 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2951749 Disease Relevance 0.81 Pain Relevance 0.39

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