INT165609

Context Info Confidence 0.59 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.43 Pain Relevance 0.08

Anatomy Link Frequency taste buds 1 BINJ 1 Lrmp (Mus musculus)

Pain Link Frequency Relevance Heat Pain 1 78.48 member 8 4 5.00

Disease Link Frequency Relevance Heat Necrosis 1 100.00 Osteoporosis 1 89.92 Disease 1 88.16 Cancer 1 75.00 Aseptic Necrosis Of Bone 1 75.00 Adhesions 2 45.16 Hypersensitivity 4 5.00 Diabetes Mellitus 2 5.00 Adenoma 2 5.00 Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because IP3R3 was coexpressed with Trpm5 in taste buds (Pérez et al. 2002), we predicted that Lrmp/Jaw1 may colocalize and interact with IP3R3.

Localization (colocalize) of Lrmp/Jaw1 in taste buds

1) Confidence 0.59 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0

Therefore, the deletion of the coiled-coil domain did not affect subcellular localization of Lrmp/Jaw1 and IP3R3 but altered its interaction with IP3R3.

Localization (localization) of Lrmp/Jaw1

2) Confidence 0.55 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0

AIMS: To highlight the misdiagnosis or delay in the detection of Bisphosphonate induced necrosis of Jaw (BINJ).

Localization (necrosis) of Jaw in BINJ associated with necrosis

3) Confidence 0.53 Published 2010 Journal Eur J Surg Oncol Section Abstract Doc Link 20071132 Disease Relevance 0.43 Pain Relevance 0.08

General Comments

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