INT16562

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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.67
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gabbr1) plasma membrane (Gabbr1) transcription factor binding (Gabbr1)
cytoplasm (Gabbr1) signal transducer activity (Gabbr1)
Anatomy Link Frequency
neurons 4
basal ganglia 2
dorsal horns 2
Gabbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 13 99.56 Very High Very High Very High
noradrenaline 1 99.38 Very High Very High Very High
mu opioid receptor 2 99.24 Very High Very High Very High
Dopamine 1 99.24 Very High Very High Very High
Glutamate 1 99.24 Very High Very High Very High
Serotonin 5 99.08 Very High Very High Very High
substance P 1 98.88 Very High Very High Very High
spinal-cord stimulation 7 98.46 Very High Very High Very High
excitatory amino acid 1 98.44 Very High Very High Very High
Neuropathic pain 10 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 48 98.88 Very High Very High Very High
Paranoid Disorders 3 97.68 Very High Very High Very High
Neuropathic Pain 22 96.40 Very High Very High Very High
Pain 33 93.52 High High
Diabetic Neuropathy 1 89.72 High High
Psychosis 3 88.72 High High
Increased Venous Pressure Under Development 1 87.84 High High
INFLAMMATION 9 86.52 High High
Dysesthesia 1 86.28 High High
Peripheral Arterial Disease 1 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, a series of experiments with novel ligands at GABAB receptors have also suggested a functional contribution of GABAB(1) expressed in peripheral nociceptive neurons; e.g. ?
Negative_regulation (suggested) of Positive_regulation (contribution) of GABAB in neurons associated with nociception
1) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.84 Pain Relevance 0.83
More recent studies indicate that SCS releases substance P serotonin, noradrenaline and GABA in the dorsal horns; activation of the GABAB receptor may be linked to a decrease in the release of glutamate and other excitatory amino acids, resulting in a decrease of neuropathic pain.
Negative_regulation (decrease) of Positive_regulation (activation) of GABAB in dorsal horns associated with neuropathic pain, gaba, glutamate, noradrenaline, serotonin, spinal-cord stimulation, substance p and excitatory amino acid
2) Confidence 0.17 Published 2009 Journal Masui Section Abstract Doc Link 19928506 Disease Relevance 1.09 Pain Relevance 1.33
Release of GABA from the terminals of hippocampal inhibitory neurons is inhibited by activation of GABAB autoreceptors and mu opioid receptors.
Negative_regulation (inhibited) of Positive_regulation (activation) of GABAB in neurons associated with gaba and mu opioid receptor
3) Confidence 0.14 Published 1993 Journal Neuron Section Abstract Doc Link 8274277 Disease Relevance 0.06 Pain Relevance 0.29
Although the pharmacology and neurobiology of paranoia remain cryptic, several mechanisms, including 5HT3 receptor-mediated dopamine release, beta-noradrenergic receptor downregulation, or GABAB receptor upregulation acting in the vicinity of the ventral basal ganglia (possibly in lateral orbitofrontal or anterior cingulate circuits), might apply to this phenomenon.
Negative_regulation (downregulation) of Positive_regulation (upregulation) of GABAB receptor in basal ganglia associated with dopamine, paranoid disorders and anterior cingulate
4) Confidence 0.10 Published 1991 Journal Clin Neuropharmacol Section Abstract Doc Link 1837756 Disease Relevance 0.59 Pain Relevance 0.40
These results indicate that GABAB receptor activation depresses GABAA receptor-mediated Ca2+ rises by both reducing the synaptic release of GABA and decreasing the postsynaptic Ca2+ responsiveness.
Negative_regulation (depresses) of Positive_regulation (activation) of GABAB associated with gaba
5) Confidence 0.06 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9497417 Disease Relevance 0.08 Pain Relevance 0.39

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