INT165620

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 14.52
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)
Anatomy Link Frequency
plasma 2
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 56 96.64 Very High Very High Very High
abdominal pain 2 90.44 High High
Inflammatory marker 4 86.56 High High
agonist 3 71.24 Quite High
peripheral neuropathy 1 11.36 Low Low
Bile 22 5.00 Very Low Very Low Very Low
Bioavailability 14 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
depression 11 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 935 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

74 100.00 Very High Very High Very High
Metabolic Disorder 2 100.00 Very High Very High Very High
Diabetes Mellitus 133 99.52 Very High Very High Very High
Hypertension 20 99.08 Very High Very High Very High
Coronary Artery Disease 179 98.68 Very High Very High Very High
Insulin Resistance 51 98.34 Very High Very High Very High
Cardiovascular Disease 147 98.32 Very High Very High Very High
Rheumatoid Arthritis 56 96.64 Very High Very High Very High
Metabolic Syndrome 146 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LPLSer(447)X variant is associated with decreased levels of plasma TGs and increased HDL cholesterol concentrations compared with wild-type LPL.
Negative_regulation (decreased) of Gene_expression (levels) of HDL in plasma associated with disorder of lipid metabolism
1) Confidence 0.41 Published 2009 Journal Curr. Opin. Mol. Ther. Section Abstract Doc Link 20072945 Disease Relevance 0.60 Pain Relevance 0.09
There was also a substantial degree of baseline dyslipidemia, defined as HDL-C <1.03 mmol/L, LDL-C ?
Negative_regulation (degree) of Gene_expression (defined) of HDL associated with disorder of lipid metabolism
2) Confidence 0.41 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012438 Disease Relevance 1.34 Pain Relevance 0
It indicated that HDL metabolic disorders and HDL maturation are blocked in the TG ?
Negative_regulation (disorders) of Gene_expression (metabolic) of HDL associated with metabolic disorder and disorder of lipid metabolism
3) Confidence 0.29 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 1.98 Pain Relevance 0
4.14 mmol/L) subjects who had a relatively low LDL-C/HDL-C ratio (2.8), the distribution in the HDL subclass was substantially altered and characterized by increased small-sized pre?
Negative_regulation (relatively) of Gene_expression (low) of HDL associated with disorder of lipid metabolism
4) Confidence 0.29 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 1.49 Pain Relevance 0
A substantial number of patients (10%) died from CVD events within 30 months, despite having LDL-C levels below 70 mg/dL (1.8 mmol/L).7 Similar were the findings in the Treating to New Targets (TNT) study, where the level of residual CVD risk remained high in patients treated with atorvastatin 10 mg/dL or 80 mg/dL.8,9 This residual CVD risk seems to depend at least partly on increased levels of triglycerides (TG) and decreased levels of high-density lipoprotein cholesterol (HDL-C).
Negative_regulation (decreased) of Gene_expression (levels) of HDL associated with cardiovascular disease and disorder of lipid metabolism
5) Confidence 0.18 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 1.41 Pain Relevance 0
DAIS was a 3-year, randomized, placebo-controlled angiographic trial.88 Fenofibrate slowed the angiographic progression of coronary atherosclerosis, along with considerable improvement in the lipid profile (LDL-C reduction by 6%, TG reduction by 28%, and HDL-C increase by 7%).
Negative_regulation (reduction) of Gene_expression (reduction) of HDL associated with coronary artery disease and disorder of lipid metabolism
6) Confidence 0.18 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 1.23 Pain Relevance 0
In addition, ERA patients exhibited a mild dyslipidemia characterized by an increase in the serum levels of total cholesterol, LDL-cholesterol, triglycerides and Apo B as well as by a decrease in the serum levels of HDL-cholesterol and Apo A-I compared with controls.
Negative_regulation (decrease) of Gene_expression (levels) of HDL associated with rheumatoid arthritis and disorder of lipid metabolism
7) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 1.42 Pain Relevance 0.30
It has been reported that insulin resistance is associated with adiposity, particularly that which is centrally deposited, which is metabolically more active than that which is peripherally deposited.3,4 Insulin resistance is also associated with hypertension and dyslipidemia (increased triglyceride and decreased HDL cholesterol levels) in type 2 diabetic subjects.4-7
Negative_regulation (decreased) of Gene_expression (levels) of HDL associated with diabetes mellitus, hypertension, insulin resistance and disorder of lipid metabolism
8) Confidence 0.15 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815832 Disease Relevance 1.70 Pain Relevance 0
Finally, inhibition of endolipase, which hydrolyzes HDL-C and decreases HDL-C levels, is another potential approach.53

Conclusion

Negative_regulation (decreases) of Gene_expression (levels) of HDL associated with disorder of lipid metabolism
9) Confidence 0.13 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.27 Pain Relevance 0.07
TC/HDL/4.41 = (6.2/1.3)/4.41 = 1.0856
Negative_regulation (/) of Gene_expression (/) of HDL associated with disorder of lipid metabolism
10) Confidence 0.11 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.44 Pain Relevance 0

General Comments

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