INT165659

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.19
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pak1) Golgi apparatus (Pak1) plasma membrane (Pak1)
nucleus (Pak1) cytoplasm (Pak1)
Anatomy Link Frequency
endometrium 6
nodules 2
Pak1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
endometriosis 4 100.00 Very High Very High Very High
Dismenorea 24 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 4 100.00 Very High Very High Very High
Dysmenorrhea 24 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparative immunohistochemical study using a monoclonal antihuman Pak1 antibody revealed that the expression of Pak1 is increased in the eutopic endometrium of women with adenomyosis during the secretory phase, along with its increased expression in adenomyotic nodules, suggesting a possible role of Pak1 in the establishment of adenomyosis.
Positive_regulation (increased) of Gene_expression (expression) of Pak1 in endometrium associated with dismenorea
1) Confidence 0.69 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 20079895 Disease Relevance 0.64 Pain Relevance 0.60
The present study was designed to evaluate whether the expression of p21-activated kinase 1 (Pak1), which recently has been shown to be increased in the eutopic endometrium of women with endometriosis, is also increased in adenomyotic nodules as well as in the eutopic endometrium in women with adenomyosis.
Positive_regulation (increased) of Gene_expression (expression) of p21-activated kinase 1 in endometrium associated with endometriosis and dismenorea
2) Confidence 0.69 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 20079895 Disease Relevance 0.50 Pain Relevance 0.52
The present study was designed to evaluate whether the expression of p21-activated kinase 1 (Pak1), which recently has been shown to be increased in the eutopic endometrium of women with endometriosis, is also increased in adenomyotic nodules as well as in the eutopic endometrium in women with adenomyosis.
Spec (whether) Positive_regulation (increased) of in nodules Spec (whether) Gene_expression (expression) of Pak1 in endometrium associated with endometriosis and dismenorea
3) Confidence 0.49 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 20079895 Disease Relevance 0.52 Pain Relevance 0.54
The present study was designed to evaluate whether the expression of p21-activated kinase 1 (Pak1), which recently has been shown to be increased in the eutopic endometrium of women with endometriosis, is also increased in adenomyotic nodules as well as in the eutopic endometrium in women with adenomyosis.
Spec (whether) Positive_regulation (increased) of in nodules Gene_expression (expression) of p21-activated kinase 1 in endometrium associated with endometriosis and dismenorea
4) Confidence 0.46 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 20079895 Disease Relevance 0.52 Pain Relevance 0.54

General Comments

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