INT165668

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.59
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 1
Slc6a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 4 99.60 Very High Very High Very High
Acute pain 8 98.32 Very High Very High Very High
gABA 18 98.28 Very High Very High Very High
Spinal cord 4 97.84 Very High Very High Very High
allodynia 28 95.76 Very High Very High Very High
Pain 16 93.04 High High
Lasting pain 2 91.72 High High
Inflammation 24 91.04 High High
spinal dorsal horn 2 87.36 High High
COX2 2 85.56 High High
Disease Link Frequency Relevance Heat
Pain 20 98.32 Very High Very High Very High
Neuropathic Pain 36 95.76 Very High Very High Very High
Nociception 2 94.04 High High
INFLAMMATION 24 91.04 High High
Low Back Pain 4 89.52 High High
Hyperalgesia 14 68.48 Quite High
Inflammatory Pain 16 50.00 Quite Low
Nervous System Injury 2 42.28 Quite Low
Catalepsy 4 38.56 Quite Low
Depression 2 28.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that the inhibitory neurotransmitter transporters are promising targets for the treatment of acute pain and that the selective inhibitor of GlyT2 could be a novel therapeutic drug.


Negative_regulation (inhibitor) of GlyT2
1) Confidence 0.48 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20081141 Disease Relevance 0 Pain Relevance 0
In this study, we examined whether a selective GlyT2 inhibitor, ALX1393, elicits an antinociceptive effect in a rat acute pain model.
Spec (whether) Negative_regulation (inhibitor) of GlyT2 associated with acute pain and antinociceptive
2) Confidence 0.48 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20081141 Disease Relevance 0.45 Pain Relevance 0.57
It is possible that at least part of the actions of NA-glycine were mediated by GLYT2 inhibition because GLYT2 is expressed at high levels within the spinal cord, and glycine receptor blockade produces allodynia in 'normal' animals and enhances nociceptive responses in pain pathways [28-30].
Negative_regulation (inhibition) of GLYT2 in spinal cord associated with nociception, pain, allodynia and spinal cord
3) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC2042976 Disease Relevance 0.62 Pain Relevance 0.85
In addition, it has recently been reported that NA-glycine inhibits the glycine transporter GLYT2, but has little effect on the glycine and GABA transporters, GLYT1 and GAT1 [27].
Negative_regulation (inhibits) of GLYT2 associated with gaba
4) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2042976 Disease Relevance 0.53 Pain Relevance 0.79

General Comments

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