INT165680

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 11.20
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
Anatomy Link Frequency
blood 1
leukocytes 1
endothelial cells 1
Hepa-1c1c7 1
brain 1
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 89 98.44 Very High Very High Very High
Inflammatory response 31 97.80 Very High Very High Very High
ischemia 39 97.36 Very High Very High Very High
cytokine 34 97.36 Very High Very High Very High
Pain 7 90.56 High High
rheumatoid arthritis 30 85.76 High High
cva 9 83.44 Quite High
Inflammatory marker 1 81.44 Quite High
cINOD 6 80.96 Quite High
antagonist 2 61.60 Quite High
Disease Link Frequency Relevance Heat
Malaria 228 99.84 Very High Very High Very High
Cerebral Malaria 132 99.36 Very High Very High Very High
INFLAMMATION 124 98.44 Very High Very High Very High
Disease 321 98.08 Very High Very High Very High
Cv Unclassified Under Development 33 97.36 Very High Very High Very High
Heart Failure 4 96.82 Very High Very High Very High
Falciparum Malaria 68 94.28 High High
Coronary Artery Disease 16 91.84 High High
Pain 6 90.56 High High
Increased Venous Pressure Under Development 5 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human umbilical vein and aortic endothelial cells, 24-48 h treatment with celecoxib induced HO-1 mRNA and protein expression and increased HO-1 enzyme activity.
Transcription (expression) of HO-1 in endothelial cells
1) Confidence 0.71 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.41 Pain Relevance 0.35
The HO-1, SOD-1, and SOD-2 transcript levels were significantly lower in the cancerous tissue, whereas no significant difference was apparent for both EGFR and HER-2 mRNA levels.
Transcription (levels) of HO-1
2) Confidence 0.65 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 1.04 Pain Relevance 0.04
In the present study, mRNA expression levels of HO-1, TLR2, and TLR4 in circulating leukocytes from BD patients were determined.
Spec (determined) Transcription (expression) of HO-1 in leukocytes associated with disease
3) Confidence 0.56 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.44 Pain Relevance 0.39
It has been shown that the (GT)n repeat is highly polymorphic and modulates the transcriptional activity of HO-1 gene [23,24].
Transcription (activity) of HO-1 gene
4) Confidence 0.53 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.35 Pain Relevance 0.08
There were no differences in mRNA expression levels of HO-1 and TLRs between HLA-B51-positive and -negative patients (Table 2).
Transcription (expression) of HO-1
5) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.72 Pain Relevance 0
Expression levels of HO-1, TLR2 and TLR4 mRNA were semiquantitatively analyzed using a real-time PCR technique, and HO-1 protein level was determined by immunoblotting in peripheral blood mononuclear cells (PBMCs) and polymorphonuclear leukocytes.
Spec (analyzed) Transcription (levels) of HO-1 in blood
6) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2374472 Disease Relevance 0.74 Pain Relevance 0.09
In Hepa-1c1c7 cells transfected with si-SQSTM1 m3 and m4, the basal mRNA level of three Nrf2-regulated genes, heme oxygenase 1, GCLC, and NAD(P)H:quinone oxidoreductase 1, was reduced significantly, between 37 and 61% compared with si-CON-transfected cells (Fig. 4A).
Transcription (level) of heme oxygenase 1 in Hepa-1c1c7
7) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
In contrast, local mRNA expression of HO-1 was unaltered by IR (Table 2).


Transcription (expression) of HO-1
8) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.75 Pain Relevance 0.25
In this study, the association between malaria disease pathogenicity/severity and (GT)n repeat polymorphism in the promoter region of the inducible HO-1 including the effect of cadmium exposure (potent inducer of HO-1 transcription) as well as polymorphism of TNF were investigated.


Transcription (transcription) of HO-1 associated with malaria and disease
9) Confidence 0.21 Published 2010 Journal Malar J Section Abstract Doc Link PMC2949743 Disease Relevance 1.50 Pain Relevance 0.08
The promoter region of HO-1 gene contains cadmium response element (CdRE), the binding site for cadmium which is a potent inducer of HO-1 transcription [14].
Transcription (transcription) of HO-1
10) Confidence 0.21 Published 2010 Journal Malar J Section Body Doc Link PMC2949743 Disease Relevance 0.88 Pain Relevance 0.03
Treatment of astrocyte (CCF-STTG1) and retinal pigment epithelial (ARPE-19, D407) cells with exogenous prostaglandin D2 (PGD2) and 15d-PGJ2 (metabolite of PGD2) consistently induced the expression of HO-1 mRNA and protein [32,33].
Transcription (expression) of HO-1 mRNA in ARPE-19 associated with heart failure
11) Confidence 0.21 Published 2010 Journal Malar J Section Body Doc Link PMC2949743 Disease Relevance 1.26 Pain Relevance 0.09
Short (GT)n alleles in the promoter region may therefore represent a genetic risk factor for cerebral malaria as in may directly enhance the transcription of HO-1 in malaria patients, and as a consequence, the products of haem degradation, i.e., CO, iron and bilirubin, may increase in the brain lesion.
Transcription (transcription) of HO-1 in brain associated with malaria and cerebral malaria
12) Confidence 0.21 Published 2010 Journal Malar J Section Body Doc Link PMC2949743 Disease Relevance 1.11 Pain Relevance 0

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