INT165681

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.29
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
Anatomy Link Frequency
endothelial cells 2
ARPE-19 2
brain 2
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 90.56 High High
Inflammation 9 83.36 Quite High
cytokine 18 81.48 Quite High
cINOD 3 81.28 Quite High
antagonist 2 61.60 Quite High
tolerance 3 41.36 Quite Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 171 99.84 Very High Very High Very High
Cerebral Malaria 99 99.60 Very High Very High Very High
Heart Failure 3 97.06 Very High Very High Very High
Disease 57 97.04 Very High Very High Very High
Falciparum Malaria 51 94.76 High High
Coronary Artery Disease 4 92.16 High High
Pain 4 90.56 High High
Infection 18 87.40 High High
Vivax Malaria 33 83.84 Quite High
INFLAMMATION 10 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human umbilical vein and aortic endothelial cells, 24-48 h treatment with celecoxib induced HO-1 mRNA and protein expression and increased HO-1 enzyme activity.
Positive_regulation (induced) of Transcription (expression) of HO-1 in endothelial cells
1) Confidence 0.69 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.41 Pain Relevance 0.35
Short (GT)n alleles in the promoter region may therefore represent a genetic risk factor for cerebral malaria as in may directly enhance the transcription of HO-1 in malaria patients, and as a consequence, the products of haem degradation, i.e., CO, iron and bilirubin, may increase in the brain lesion.
Positive_regulation (enhance) of Transcription (transcription) of HO-1 in brain associated with malaria and cerebral malaria
2) Confidence 0.18 Published 2010 Journal Malar J Section Body Doc Link PMC2949743 Disease Relevance 1.11 Pain Relevance 0
In this study, the association between malaria disease pathogenicity/severity and (GT)n repeat polymorphism in the promoter region of the inducible HO-1 including the effect of cadmium exposure (potent inducer of HO-1 transcription) as well as polymorphism of TNF were investigated.


Positive_regulation (inducer) of Transcription (transcription) of HO-1 associated with malaria and disease
3) Confidence 0.18 Published 2010 Journal Malar J Section Abstract Doc Link PMC2949743 Disease Relevance 1.50 Pain Relevance 0.08
Treatment of astrocyte (CCF-STTG1) and retinal pigment epithelial (ARPE-19, D407) cells with exogenous prostaglandin D2 (PGD2) and 15d-PGJ2 (metabolite of PGD2) consistently induced the expression of HO-1 mRNA and protein [32,33].
Positive_regulation (induced) of Transcription (expression) of HO-1 mRNA in ARPE-19 associated with heart failure
4) Confidence 0.18 Published 2010 Journal Malar J Section Body Doc Link PMC2949743 Disease Relevance 1.27 Pain Relevance 0.09

General Comments

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