INT165690

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Context Info
Confidence 0.79
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.31
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcc2) ATPase activity (Abcc2) transmembrane transport (Abcc2)
Anatomy Link Frequency
plasma 1
Hepatocytes 1
liver 1
bile 1
Abcc2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 12 100.00 Very High Very High Very High
diclofenac 20 96.72 Very High Very High Very High
agonist 2 88.76 High High
Cancer pain 2 84.20 Quite High
rheumatoid arthritis 2 82.56 Quite High
Perioperative pain 2 81.68 Quite High
Inflammation 2 79.08 Quite High
Analgesic 2 78.20 Quite High
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lipodystrophy 2 99.68 Very High Very High Very High
Breast Cancer 3 92.88 High High
Targeted Disruption 16 88.40 High High
Cancer Pain 2 84.20 Quite High
Rheumatoid Arthritis 2 82.56 Quite High
Post Operative Pain 2 81.68 Quite High
INFLAMMATION 2 79.08 Quite High
Disease 1 69.84 Quite High
Hematological Disease 6 54.80 Quite High
Hepatotoxicity 4 51.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of Mrp2 and Bcrp1, localized at the canalicular membrane of hepatocytes, leads to impaired biliary excretion of acyl glucuronides and consequently to elevated liver and plasma levels.
Localization (localized) of Mrp2 in liver
1) Confidence 0.79 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20086033 Disease Relevance 0.47 Pain Relevance 0.60
Hepatocytes secrete biliary phospholipids, composed largely of phosphatidylcholine (PC), through multidrug-resistance 2 P-glycoprotein (MDR3, or ABCB4) embedded in the canalicular membrane.
Localization (secrete) of multidrug-resistance 2 P-glycoprotein in Hepatocytes
2) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.21 Pain Relevance 0.13
The absence of Mrp2 and Bcrp1, localized at the canalicular membrane of hepatocytes, leads to impaired biliary excretion of acyl glucuronides and consequently to elevated liver and plasma levels.
Localization (localized) of Mrp2 in plasma
3) Confidence 0.27 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20086033 Disease Relevance 0.47 Pain Relevance 0.60
To decipher the molecular basis of Kit-dependent steatosis, we determined the expression profiles of key genes involved in lipid hepatic metabolism: such as apoliproteins (Apoa1, ApoB), lipoprotein receptors (LdlR, VldlR, Scarb1, Lrp1), lipase (Lipc, LipH, Lpl) and others implicated in hepatic lipidogenesis (Scap, Srebf1, Srebf2), lipid secretion (Pltp, Mttp, Abca1), bile acid synthesis (Cyp8b1, Cyp7a1), lipid transport (Slc10a1, Abcb11, Abcb1a, Abcc2) and a lipodystrophy gene, Lipin 1 (Lpin1), encoding a phosphatidate phosphatase enzyme with transcription activity [26-28].
Localization (secretion) of Abcc2 in bile associated with bile and lipodystrophy
4) Confidence 0.26 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.15 Pain Relevance 0.05

General Comments

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