INT165702

Context Info Confidence 0.35 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 11 Disease Relevance 2.18 Pain Relevance 1.48

mRNA processing (Son) RNA binding (Son) nucleus (Son) intracellular (Son) cell cycle (Son) DNA binding (Son)

Anatomy Link Frequency fat 2 arcuate nucleus 1 SON 1 Son (Mus musculus)

Pain Link Frequency Relevance Heat Cholecystokinin 32 99.46 long-term potentiation 13 98.68 cerebral cortex 5 94.48 Limbic system 1 93.12 amygdala 44 92.08 nMDA receptor 27 91.40 Thalamus 12 89.20 Hippocampus 14 88.32 Spinal cord 2 87.48 medulla 114 87.44

Disease Link Frequency Relevance Heat Anxiety Disorder 344 98.32 Obesity 228 95.76 Targeted Disruption 26 71.52 Depression 85 68.00 Stress 50 62.96 Appetite Loss 40 43.68 Aggression 2 23.04 Urological Neuroanatomy 1 17.12 Increased Venous Pressure Under Development 5 13.48 Neurodegenerative Disease 2 9.76

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A recent study demonstrated that an N-terminal splice variant of the transient receptor potential vanilloid type 1 (TRPV1) is essential for osmosensory transduction in the SON.

Gene_expression (transduction) of SON in SON

1) Confidence 0.35 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20089896 Disease Relevance 0 Pain Relevance 0.09

Confirming microarray data, ISH revealed a decreased expression of Avp in both the PVN (Fig. 1D) and SON (Fig. 2A) in male LAB compared to both HAB and NAB mice (PVN: p<0.01 vs.

Gene_expression (expression) of SON associated with anxiety disorder

2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.77 Pain Relevance 0.08

Similarly, qPCR analysis showed a reduced Avp expression in the PVN (Fig. 1E) and SON (Fig. 2B) of both male and female LABs compared to HAB or NAB animals (PVN of male mice: p<0.05 vs.

Gene_expression (expression) of SON associated with anxiety disorder

3) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.67 Pain Relevance 0.07

Due to the high expression of Avp and Oxt mRNAs in the hypothalamic PVN and SON, we focused on these nuclei in LAB, HAB, NAB or F1 animals.

Gene_expression (expression) of SON associated with anxiety disorder

4) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.10 Pain Relevance 0.15

In support of an allele-dependent effect, heterozygous F1 mice revealed intermediate levels of Avp mRNA expression in the SON in comparison to LABs and HABs (p<0.1 F1 vs.

Gene_expression (expression) of SON

5) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.27 Pain Relevance 0.03

and eNOS (Son et al., 1996) although the data on nNOS?

Gene_expression (al.) of Son

6) Confidence 0.13 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.07 Pain Relevance 0.24

In contrast, there are few CRH-positive fibers in the magnocellular subdivision of PVN and SON, where vasopressin is strongly expressed (Itoi et al. 2004).

Gene_expression (expressed) of SON

7) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.06 Pain Relevance 0.38

All three MSHs activate IEGs in the SON and coexpression with fluorogold suggests that all of these targets activated by ?

Gene_expression (coexpression) of SON

8) Confidence 0.08 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0 Pain Relevance 0.08

MC4R alone is expressed in the SON and MC4R ko mice are particularly prone to gaining weight on a high fat diet, even when compared with ob/ob mice [165].

Gene_expression (expressed) of SON in fat associated with obesity

9) Confidence 0.08 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.10 Pain Relevance 0.09

CCK co-expression in oxytocin neurones in the SON occurs in rats on a normal diet only, rather than a high fat diet [164].

Gene_expression (neurones) of SON in fat associated with cholecystokinin

10) Confidence 0.08 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.08 Pain Relevance 0.14

Again, this may reflect indirect activation, perhaps via an arcuate nucleus POMC neuronal projection to the SON, as evidenced by immunocytochemical detection of POMC fibres between these nuclei and in situ hybridisation for MC3R in the arcuate nucleus and MC4R in the SON (Table 1; [90,93,118]).

Gene_expression (projection) of SON in arcuate nucleus

11) Confidence 0.08 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.06 Pain Relevance 0.13

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