INT165706

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.05
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) enzyme binding (PPARG) DNA binding (PPARG)
lipid metabolic process (PPARG) cytoplasm (PPARG) cytosol (PPARG)
Anatomy Link Frequency
adipocytes 2
PPARG (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 99.96 Very High Very High Very High
Spinal cord 4 64.64 Quite High
Inflammation 2 55.64 Quite High
Pain 2 54.96 Quite High
cINOD 2 53.84 Quite High
nud 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 40 98.00 Very High Very High Very High
Hyperlipidemia 4 80.72 Quite High
Appetite Loss 44 77.08 Quite High
Alzheimer's Dementia 4 72.24 Quite High
Body Weight 12 65.56 Quite High
INFLAMMATION 4 55.64 Quite High
Pain 2 54.96 Quite High
Overweight 5 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Metabolic Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein knockdown with small interfering RNA specific for PPARgamma blocks RhoA suppression of PPARgamma agonists in PC12 cells.
Negative_regulation (knockdown) of Negative_regulation (suppression) of PPARgamma associated with agonist
1) Confidence 0.23 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20089905 Disease Relevance 0.31 Pain Relevance 0.30
Protein knockdown with small interfering RNA specific for PPARgamma blocks RhoA suppression of PPARgamma agonists in PC12 cells.
Negative_regulation (blocks) of Negative_regulation (suppression) of PPARgamma associated with agonist
2) Confidence 0.23 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20089905 Disease Relevance 0.29 Pain Relevance 0.29
It is theorized that Irvingia gabonensis works by inhibiting adipogenesis by down-regulating peroxisome proliferator-activated receptor gamma (PPAR-gamma) which is responsible for the differentiation of adipocytes.
Negative_regulation (down) of Negative_regulation (regulating) of PPAR-gamma in adipocytes associated with obesity
3) Confidence 0.13 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2931392 Disease Relevance 0.45 Pain Relevance 0

General Comments

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