INT16572

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Context Info
Confidence 0.12
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.22
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
enteric nerves 3
epithelium 1
Cl (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 20 98.82 Very High Very High Very High
agonist 12 96.64 Very High Very High Very High
antagonist 4 96.60 Very High Very High Very High
Serotonin 4 96.12 Very High Very High Very High
tetrodotoxin 9 92.08 High High
Inflammatory mediators 2 75.00 Quite High
Potency 2 43.24 Quite Low
Central nervous system 8 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
TRP channel 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 75.00 Quite High
Targeted Disruption 12 70.56 Quite High
Pressure And Volume Under Development 13 48.64 Quite Low
Cystic Fibrosis 8 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Vitelliform Macular Dystrophy 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Initially, F81C VRAC currents recorded with symmetrical Cl?
Localization (symmetrical) of Cl
1) Confidence 0.12 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2571971 Disease Relevance 0 Pain Relevance 0
From these data it was concluded that: 1) histamine interacts with H1-receptors to increase Na and Cl secretion and inhibit Cl absorption; 2) prostaglandin E2 inhibits a HCO3-dependent Cl absorptive pathway, possibly involving Cl/HCO3 exchange and 3) leukotriene C4 acts on enteric nerves to stimulate Cl secretion.
Localization (secretion) of Cl in enteric nerves
2) Confidence 0.05 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093732 Disease Relevance 0.07 Pain Relevance 0.29
From these data it was concluded that: 1) histamine interacts with H1-receptors to increase Na and Cl secretion and inhibit Cl absorption; 2) prostaglandin E2 inhibits a HCO3-dependent Cl absorptive pathway, possibly involving Cl/HCO3 exchange and 3) leukotriene C4 acts on enteric nerves to stimulate Cl secretion.
Localization (secretion) of Cl in enteric nerves
3) Confidence 0.05 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093732 Disease Relevance 0.07 Pain Relevance 0.19
The increase in Isc was dependent on the presence of Cl- and HCO3- anions in the medium, but it was not affected by inhibitors of Cl-secretion such as furosemide or a Cl- channel blocker.
Localization (secretion) of Cl
4) Confidence 0.03 Published 1991 Journal Eicosanoids Section Abstract Doc Link 1838696 Disease Relevance 0 Pain Relevance 0.09
We conclude that PAF causes changes in ion transport that include Cl- secretion and acts on the epithelium possibly via an intermediate cell and enteric nerves.
Localization (secretion) of Cl in enteric nerves
5) Confidence 0.03 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2597284 Disease Relevance 0 Pain Relevance 0.23
In conclusion, SRIF decreases basal as well as both cAMP and Ca(2+)-dependent Cl- secretion in rat colonic mucosa.
Localization (secretion) of Cl associated with somatostatin
6) Confidence 0.03 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8532068 Disease Relevance 0 Pain Relevance 0.46
Both conductances, however, could contribute to the secretion of Cl- and HCO3- into the CSF, if they are expressed in the apical membrane of the epithelium.


Localization (secretion) of Cl in epithelium
7) Confidence 0.02 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0.07 Pain Relevance 0

General Comments

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