INT165726

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.16
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Anxa1) cilium (Anxa1) protein complex (Anxa1)
cytoplasm (Anxa1) extracellular space (Anxa1) signal transduction (Anxa1)
Anatomy Link Frequency
dorsal root 1
smooth muscle 1
cerebrospinal fluid 1
Anxa1 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 4 100.00 Very High Very High Very High
cINOD 2 99.84 Very High Very High Very High
Spinal cord 80 96.56 Very High Very High Very High
qutenza 18 94.52 High High
Neuropathic pain 48 93.60 High High
Inflammation 6 93.60 High High
Sciatic nerve 22 92.68 High High
spinal dorsal horn 10 89.68 High High
withdrawal 75 88.16 High High
Dorsal horn 8 85.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.64 Very High Very High Very High
Hypersensitivity 120 99.48 Very High Very High Very High
Nervous System Injury 35 94.60 High High
Neuropathic Pain 65 93.60 High High
Urological Neuroanatomy 10 92.40 High High
Ganglion Cysts 22 92.20 High High
Cancer 4 91.36 High High
Pancreatic Cancer 1 77.16 Quite High
Pain 24 66.48 Quite High
Demyelinating Disease 14 65.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo.
Positive_regulation (induced) of Annexin 1 associated with aspirin, inflammation and cinod
1) Confidence 0.29 Published 2010 Journal Cancer Res. Section Title Doc Link 20215502 Disease Relevance 0.75 Pain Relevance 0.55
An increase in LPC-induced LPA was observed with a similar time-course in dorsal root (DR) preparations.
Positive_regulation (increase) of LPC in dorsal root
2) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.29
ATX and LPA3 receptors are required in LPC-induced LPA production
Positive_regulation (required) of LPC
3) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.18 Pain Relevance 0.33
The role of TRPM8 in mediating LPC evoked cold hypersensitivity was investigated in mice, taking advantage of the availability of genetically modified animals lacking TRPM8.
Positive_regulation (mediating) of LPC associated with hypersensitivity
4) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.62 Pain Relevance 0.41
Our data demonstrate that iPLA2 activity is required for icilin-induced cold hypersensitivity, which is mediated exclusively by TRPM8, and that LPC-induced increases in cold sensitivity depend on the presence of TRPM8.
Positive_regulation (increases) of LPC-induced associated with hypersensitivity
5) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.34 Pain Relevance 0.03
Preparations with no attached longitudinal smooth muscle layer (and also myenteric layer) generated SPC alone, while those with no attached submucosal layer generated only LPC, indicating that the pacemakers of the LPC and SPC are distributed in the myenteric and submucosal layers, respectively.
Positive_regulation (generated) of LPC in smooth muscle
6) Confidence 0.03 Published 2009 Journal J Smooth Muscle Res Section Abstract Doc Link 20093794 Disease Relevance 0 Pain Relevance 0
In intact preparations, muscarinic stimulation with acetylcholine increased the frequency of LPC, while nitrergic stimulation with sodium nitroprusside reduced the amplitude and frequency of LPC, and also the amplitude but not the frequency of SPC.
Positive_regulation (increased) of LPC
7) Confidence 0.03 Published 2009 Journal J Smooth Muscle Res Section Abstract Doc Link 20093794 Disease Relevance 0 Pain Relevance 0.13
ATX protein is present in the cerebrospinal fluid (CSF) and has lysoPLD activity to convert LPC into LPA [22].
Positive_regulation (convert) of LPC in cerebrospinal fluid
8) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 1.28 Pain Relevance 0.83

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