INT165765

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.07
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tnfsf11, Nfkb1) cell differentiation (Tnfsf11) mitochondrion (Nfkb1)
intracellular (Tnfsf11) DNA binding (Nfkb1) protein complex (Nfkb1)
Anatomy Link Frequency
osteoblast 1
Tnfsf11 (Mus musculus)
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 3 96.52 Very High Very High Very High
agonist 1 96.12 Very High Very High Very High
antagonist 2 83.72 Quite High
Inflammation 1 72.76 Quite High
Pain 1 72.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1 98.44 Very High Very High Very High
Osteoporosis 11 93.64 High High
Hypercalcemia 3 90.84 High High
INFLAMMATION 1 72.76 Quite High
Pain 1 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsazepine also suppressed RANKL induced IkappaB and ERK1/2 phosphorylation and caused apoptosis of mature osteoclasts and also inhibited alkaline phosphatase activity and bone nodule formation in calvarial osteoblast cultures.
RANKL Positive_regulation (induced) of IkappaB in osteoblast associated with osteoporosis and apoptosis
1) Confidence 0.01 Published 2010 Journal Bone Section Abstract Doc Link 20096813 Disease Relevance 1.07 Pain Relevance 0.33

General Comments

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