INT165773

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 37
Total Number 47
Disease Relevance 22.28
Pain Relevance 14.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Darc) signal transducer activity (Darc)
Anatomy Link Frequency
endothelial cells 4
neutrophils 4
juvenile 3
lymph node 2
brain 2
Darc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1461 100.00 Very High Very High Very High
Inflammation 736 100.00 Very High Very High Very High
cytokine 191 100.00 Very High Very High Very High
Arthritis 600 99.52 Very High Very High Very High
Glutamate 238 98.48 Very High Very High Very High
tolerance 17 96.68 Very High Very High Very High
imagery 106 93.20 High High
methotrexate 168 86.12 High High
anesthesia 29 83.60 Quite High
Nicotine 96 75.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 819 100.00 Very High Very High Very High
Apoptosis 396 100.00 Very High Very High Very High
Glaucoma 392 100.00 Very High Very High Very High
Injury 232 99.64 Very High Very High Very High
Ocular Hypertension 105 99.58 Very High Very High Very High
Juvenile Chronic Polyarthritis 480 99.52 Very High Very High Very High
Breast Cancer 12 99.44 Very High Very High Very High
Metastasis 6 98.80 Very High Very High Very High
Cerebral Malaria 195 98.56 Very High Very High Very High
Arthritis 120 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DARC receptors expressed on erythrocytes and also on endothelial cells have been shown to function as sinks and so could differentially regulate recruitment [48].
Gene_expression (expressed) of DARC in endothelial cells
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.44 Pain Relevance 0.16
Among individuals with the CC genotype, DARC is not expressed (http://www.utdol.com/utd/content/topic.do?
Neg (not) Gene_expression (expressed) of DARC associated with chemokine
2) Confidence 0.67 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2655355 Disease Relevance 0.29 Pain Relevance 0.22
In a linear regression model that included percentage African ancestry, national origin, cytokines, socio-economic factors and the ELA2 rs57834246 SNP, only the DARC rs2814778 genotype and C-reactive protein were associated with ANC (P < 0·0001).
Gene_expression (rs2814778 genotype) of DARC associated with cytokine
3) Confidence 0.58 Published 2008 Journal British Journal of Haematology Section Abstract Doc Link PMC2655355 Disease Relevance 0.37 Pain Relevance 0.09
Individuals who lack DARC on their red blood cells may still express it on their postcapillary venules, where it may interfere with leucocyte trafficking (Peiper et al, 1995; Kashiwazaki et al, 2003; Nibbs et al, 2003).
Neg (lack) Gene_expression (lack) of DARC in red blood cells associated with chemokine
4) Confidence 0.58 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2655355 Disease Relevance 0.30 Pain Relevance 0.34
In a small study (n = 75) of human breast cancer pathological samples, high DARC expressors were less likely than low DARC expressors to have extensive lymph node metastases and had lower mortality (Wang et al, 2006).
Gene_expression (expressors) of DARC in lymph node associated with chemokine, breast cancer and metastasis
5) Confidence 0.51 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2655355 Disease Relevance 0.40 Pain Relevance 0.39
In a small study (n = 75) of human breast cancer pathological samples, high DARC expressors were less likely than low DARC expressors to have extensive lymph node metastases and had lower mortality (Wang et al, 2006).
Gene_expression (expressors) of DARC in lymph node associated with chemokine, breast cancer and metastasis
6) Confidence 0.51 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2655355 Disease Relevance 0.40 Pain Relevance 0.38
DARC is expressed by vascular endothelium and is present on RBCs.
Gene_expression (expressed) of DARC in vascular endothelium
7) Confidence 0.49 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.50
Assessment of coenzyme Q10 in glaucoma-related models with DARC
Gene_expression (models) of DARC associated with glaucoma
8) Confidence 0.48 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.09 Pain Relevance 0.03
The gene that controls expression of the Duffy antigen receptor for chemokines (DARC), located on chromosome 1, has long been known to be associated with race.
Gene_expression (expression) of DARC associated with chemokine
9) Confidence 0.45 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2655355 Disease Relevance 0.36 Pain Relevance 0.24
DARC is expressed by vascular endothelium and is present on RBCs.
Gene_expression (present) of DARC in vascular endothelium
10) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.51
pathway in experimental glaucoma with DARC
Gene_expression (pathway) of DARC associated with glaucoma
11) Confidence 0.42 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.22 Pain Relevance 0.05
In a well-established rat model of chronic ocular hypertension (OHT) (Cordeiro et al., 2004; Guo et al., 2005a, b, 2006, 2007), using DARC we revealed that RGC apoptosis occurs in vivo, accounting for 1, 15, 13, 7, and 2% of total RGCs, with RGC losses of 17, 22, 36, 45, and 60% of the original population at 2, 3, 4, 8, and 16 weeks, respectively, after surgical elevation of IOP.
Gene_expression (using) of DARC associated with apoptosis and ocular hypertension
12) Confidence 0.42 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 0.89 Pain Relevance 0.20
Our DARC data strongly supports the involvement of glutamate in glaucoma (Guo et al., 2006; Salt and Cordeiro, 2006).


Gene_expression (data) of DARC associated with glutamate and glaucoma
13) Confidence 0.42 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.28 Pain Relevance 0.17
We then applied the most optimal combination regimens of MK801 and LY354740 to an OHT model at different time points (0, 1, and 2 weeks after IOP elevation), and our DARC results revealed that the most effective timing of the treatment application was at 0 weeks (the time of IOP elevation) (p<0.05, Fig. 2).
Gene_expression (results) of DARC associated with ocular hypertension
14) Confidence 0.42 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 0.74 Pain Relevance 0.19
Using DARC, we have highlighted that A?
Gene_expression (Using) of DARC
15) Confidence 0.42 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.01 Pain Relevance 0
Endothelial cell–expressed DARC may be able to transcytose certain chemokines, although this finding is controversial (17, 18).
Gene_expression (expressed) of DARC in Endothelial cell associated with chemokine
16) Confidence 0.38 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.07 Pain Relevance 0.50
Detection of RGC apoptosis in glaucoma-related animal models with DARC
Gene_expression (Detection) of DARC associated with glaucoma and apoptosis
17) Confidence 0.37 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 0.79 Pain Relevance 0.24
Expression of endogenous mouse cytokines and chemokines
Gene_expression (Expression) of chemokines associated with chemokine and cytokine
18) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.13 Pain Relevance 0.46
During the process of trafficking and in the target tissue, the first wave of neutrophils trigger expression of a wide variety of molecules including expression of cytokines and chemokines.
Gene_expression (expression) of chemokines in neutrophils associated with chemokine and cytokine
19) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.16 Pain Relevance 0.52
Monomeric and GAG-binding-deficient mutants of CC chemokines RANTES/CCL5, MIP-1?
Gene_expression (/) of chemokines associated with chemokine
20) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.17 Pain Relevance 0.34

General Comments

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