INT165774

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.95
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Darc) signal transducer activity (Darc)
Anatomy Link Frequency
synovial fluid 1
lymphocytes 1
bladder 1
Darc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 266 100.00 Very High Very High Very High
Inflammation 160 100.00 Very High Very High Very High
Arthritis 250 97.68 Very High Very High Very High
methotrexate 70 93.44 High High
interstitial cystitis 2 50.00 Quite Low
rheumatoid arthritis 45 48.24 Quite Low
cINOD 5 31.60 Quite Low
antagonist 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Rheumatism 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 155 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 200 97.68 Very High Very High Very High
Disease 50 78.32 Quite High
Interstitial Cystitis 2 50.64 Quite High
Arthritis 50 49.76 Quite Low
Rheumatoid Arthritis 45 48.24 Quite Low
Coagulation Disorder 10 5.00 Very Low Very Low Very Low
Necrosis 10 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Hyperplasia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased transcription of inflammatory chemokines in synovial fluid cells
Transcription (transcription) of chemokines in synovial fluid associated with chemokine and inflammation
1) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.74 Pain Relevance 0.45
After separation into myeloid and lymphoid populations, RT-PCR of CCL3 and CXCL10 on separated cells from three JIA patients (one persistent oligoarticular, one extended oligoarticular, and one polyarticular) showed that these two chemokines were transcribed predominantly in the myeloid population (Figure 1b) as also seen in controls (data not shown).
Transcription (transcribed) of chemokines associated with chemokine and arthritis
2) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.43 Pain Relevance 0.36
To further quantify transcription of these chemokines in synovial lymphocytes, purified CD3+ cells (2 × 106) from PBMCs and SFMCs from 15 JIA patients (5 persistent oligoarticular, 5 extended oligoarticular, 5 polyarticular) were used to prepare cDNA for semi-quantitative RT-PCR.
Transcription (transcription) of chemokines in lymphocytes associated with chemokine and arthritis
3) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.36 Pain Relevance 0.27
Both of these chemokines were shown to be predominantly transcribed in cells of myeloid origin from these samples, but no clear differences in mRNA levels were seen between the two compartments in these samples.
Transcription (transcribed) of chemokines associated with chemokine
4) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.68 Pain Relevance 0.71
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
Transcription (Levels) of chemokines associated with chemokine and inflammation
5) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.69 Pain Relevance 0.43
Quantitative real-time polymerase chain reaction confirmed increased mRNA expression of several genes in the bladder samples of patients with ulcerative interstitial cystitis, including CXCR3 binding chemokines (CXCL9, 10 and 11) and TNFSF14 (LIGHT).
Transcription (expression) of chemokines in bladder
6) Confidence 0.00 Published 2010 Journal J. Urol. Section Body Doc Link 20096889 Disease Relevance 0.05 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox