INT165776

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.94
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Darc) signal transducer activity (Darc)
Anatomy Link Frequency
leukocyte 2
lymphocytes 1
bladder 1
memory T cells 1
Darc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 234 100.00 Very High Very High Very High
Inflammation 113 100.00 Very High Very High Very High
cytokine 45 92.92 High High
imagery 105 76.24 Quite High
Arthritis 62 73.76 Quite High
Catecholamine 2 57.00 Quite High
interstitial cystitis 4 50.00 Quite Low
agonist 1 38.60 Quite Low
cINOD 4 38.44 Quite Low
positron emission tomography 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 125 100.00 Very High Very High Very High
Neutropenia 18 100.00 Very High Very High Very High
Cold Sores 65 97.28 Very High Very High Very High
Infection 59 93.84 High High
Sickle Cell Anemia 6 91.84 High High
Cancer 22 88.68 High High
Malaria 2 87.36 High High
Hypersensitivity 22 85.88 High High
Keratitis 37 82.92 Quite High
Increased Venous Pressure Under Development 5 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism for the association of neutropenia with the DARC SNP is unknown.
DARC Binding (association) of associated with neutropenia and chemokine
1) Confidence 0.42 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2655355 Disease Relevance 0.32 Pain Relevance 0.40
The gene that controls expression of the Duffy antigen receptor for chemokines (DARC), located on chromosome 1, has long been known to be associated with race.
DARC Binding (associated) of associated with chemokine
2) Confidence 0.28 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2655355 Disease Relevance 0.35 Pain Relevance 0.24
Our data place CCRL2 in a class of atypical receptors that include D6, DARC, and CCX-CKR, all of which bind to chemoattractants but do not support classical ligand-driven signal transduction (for review see reference 11).
DARC Neg (not) Binding (bind) of
3) Confidence 0.23 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.08
The entry of HSV-1 into cells is well known to require membrane fusion between the virus envelope and cell membrane, which is primarily mediated by the interaction of the viral ligand, glycoprotein D(gD)and its cellular receptor HVEM [33-35].
glycoprotein D Binding (interaction) of associated with cold sores
4) Confidence 0.18 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.91 Pain Relevance 0.15
These observations suggest that dimerization of CC chemokines is essential only for GAG-related function and monomers are essential only for GPCR-related function.
chemokines Binding (dimerization) of associated with chemokine
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.08 Pain Relevance 0.30
Recruitment could also involve other interactions such as binding to non-canonical receptors, non-signaling chemokine receptor DARC, or proteolysis by leukocyte-released proteases [47]–[49].
chemokine receptor DARC Binding (binding) of in leukocyte associated with chemokine
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.48 Pain Relevance 0.18
A hypothetical framework for migration of leukocytes and lymphocytes in tissues is provided by the multistage guidance of leukocytes by chemokines and bacterial products [35], and by the concept that antigen receptor engagement delivers a stop signal for lymphocytes [36].
antigen receptor Binding (engagement) of in leukocytes associated with chemokine
7) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165062 Disease Relevance 0.05 Pain Relevance 0.26
Functionally distinct subsets of leukocytes express different chemokine receptors: thus, recently activated, effector and memory T cells express high levels of the receptors that bind inflammatory chemokines, thought to facilitate their accumulation at inflammatory sites, compared to naïve cells.
chemokines Binding (bind) of in memory T cells associated with chemokine and inflammation
8) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.70 Pain Relevance 0.53
A hypothetical framework for migration of leukocytes and lymphocytes in tissues is provided by the multistage guidance of leukocytes by chemokines and bacterial products [35], and by the concept that antigen receptor engagement delivers a stop signal for lymphocytes [36].
antigen receptor Binding (engagement) of in lymphocytes associated with chemokine
9) Confidence 0.00 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165062 Disease Relevance 0.05 Pain Relevance 0.26
CONCLUSIONS: Our study using DNA microarray analysis followed by quantitative real-time polymerase chain reaction reveals over expression of genes related to immune and inflammatory responses, including T-helper type 1 related chemokines, and cytokines such as CXCR3 binding chemokines and TNFSF14.
chemokines Binding (binding) of
10) Confidence 0.00 Published 2010 Journal J. Urol. Section Body Doc Link 20096889 Disease Relevance 0 Pain Relevance 0
Quantitative real-time polymerase chain reaction confirmed increased mRNA expression of several genes in the bladder samples of patients with ulcerative interstitial cystitis, including CXCR3 binding chemokines (CXCL9, 10 and 11) and TNFSF14 (LIGHT).
chemokines Binding (binding) of in bladder
11) Confidence 0.00 Published 2010 Journal J. Urol. Section Body Doc Link 20096889 Disease Relevance 0 Pain Relevance 0

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