INT165787

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RYR2) transmembrane transport (RYR2)
Anatomy Link Frequency
heart 1
RYR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 1 75.00 Quite High
Pain 1 71.20 Quite High
imagery 5 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arrhythmogenic Right Ventricular Dysplasia 45 94.32 High High
Malignant Hyperthermia 1 93.68 High High
Sudden Death 2 92.64 High High
Muscle Disease 1 90.40 High High
Myocardial Infarction 1 81.04 Quite High
Disease 21 75.12 Quite High
Epilepsy 1 73.52 Quite High
Pain 1 71.20 Quite High
Cancer 1 70.48 Quite High
Adhesions 5 45.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although RyRs are expressed in many cell types, their roles have only been extensively characterised in tissues in which they are abundant: RyR1 is essential for excitation-contraction coupling in skeletal muscle; whereas RyR2 is required for the analogous signal transduction pathway in heart.
Positive_regulation (required) of RyR2 in heart
1) Confidence 0.23 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20097179 Disease Relevance 0.61 Pain Relevance 0.11
To date, the genetic defect that causes ARVC6 has not been identified.


Positive_regulation (causes) of ARVC6
2) Confidence 0.16 Published 2006 Journal BMC Med Genet Section Abstract Doc Link PMC1444927 Disease Relevance 0.69 Pain Relevance 0

General Comments

This test has worked.

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