INT165799

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.12
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1)
cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)
Anatomy Link Frequency
hepatocytes 2
neurons 2
Bcl2l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 84 99.12 Very High Very High Very High
Paracetamol 1 84.40 Quite High
cytokine 20 52.80 Quite High
depression 2 35.36 Quite Low
Inflammation 18 32.04 Quite Low
cva 24 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 134 100.00 Very High Very High Very High
Cv Unclassified Under Development 38 99.12 Very High Very High Very High
Cv General 4 Under Development 9 98.16 Very High Very High Very High
Hemorrhagic Shock 18 97.84 Very High Very High Very High
Retina Disease 34 97.40 Very High Very High Very High
Hepatotoxicity 5 97.04 Very High Very High Very High
Hypothermia 138 95.60 Very High Very High Very High
Stress 12 95.40 Very High Very High Very High
Ocular Hypertension 16 83.84 Quite High
Toxicity 1 76.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our results showing a time-related decrease in Bcl-xL expression in the retina following I/R are in conflict with a publication on hippocampal neurons, where no alteration of the abundance of Bcl-xL was observed following I/R [27].
Negative_regulation (decrease) of Gene_expression (expression) of Bcl-xL in neurons
1) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.47 Pain Relevance 0.05
It clearly finds an association with an increase in Bax with a decrease in Bcl-xL expression and negates any involvement of Bak and Bcl-2 regulations in the damage induced by retinal ischemia 24 h after reperfusion.
Negative_regulation (decrease) of Gene_expression (expression) of Bcl-xL associated with ischemia and retina disease
2) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.71 Pain Relevance 0.17
Moreover, DMF+CCl(4) caused PARP cleavage and caspase-3 activation, but decreased the level of Bcl-xL, all of which confirmed apoptosis of hepatocytes.
Negative_regulation (decreased) of Gene_expression (level) of Bcl-xL in hepatocytes associated with apoptosis
3) Confidence 0.25 Published 2010 Journal Chem. Biol. Interact. Section Abstract Doc Link 20097184 Disease Relevance 0.88 Pain Relevance 0.08
In a rabbit model of ischemia-reperfusion, hypothermic animals exhibited decreased expression of pro-apoptotic proteins, transformation-related protein (p53) and bak, and an increased expression of anti-apoptotic Bcl-2 homologue Bcl-x [100].
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-x associated with ischemia and apoptosis
4) Confidence 0.16 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.74 Pain Relevance 0.14
However, the Bcl-xL expression decreased to 50% at 48 h, whereas a concomitant increase of the pro-apoptotic Bax protein could be deteced.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-xL associated with apoptosis
5) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.84 Pain Relevance 0.03
However, expression of Bcl-xL decreased at the following days to equal levels in both groups (figure 2A).
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-xL
6) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.48 Pain Relevance 0

General Comments

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