INT16580

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 3.80
Pain Relevance 9.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) cell death (Htr2a) aging (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
plasma 1
head 1
Htr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 42 100.00 Very High Very High Very High
antagonist 29 100.00 Very High Very High Very High
dopamine receptor 16 100.00 Very High Very High Very High
sSRI 2 99.62 Very High Very High Very High
noradrenaline 17 99.52 Very High Very High Very High
Desipramine 13 99.50 Very High Very High Very High
Kinase C 18 99.48 Very High Very High Very High
Serotonin 17 99.16 Very High Very High Very High
fluoxetine 34 98.70 Very High Very High Very High
Neuropeptide 4 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperglycemia 3 98.96 Very High Very High Very High
Anxiety Disorder 6 98.84 Very High Very High Very High
Aggression 15 98.76 Very High Very High Very High
Body Weight 5 98.10 Very High Very High Very High
Shock 3 91.48 High High
Hyperalgesia 8 89.48 High High
Hypotension 1 87.28 High High
Convulsion 7 85.12 High High
Urological Neuroanatomy 3 75.00 Quite High
Neuropathic Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, chronic administration of imipramine, mianserin, and tranylcypromine, treatments that decreased ligand binding, did not decrease levels of 5-HT2 receptor mRNA.
Neg (not) Negative_regulation (decrease) of 5-HT2
1) Confidence 0.57 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.56 Pain Relevance 0.23
Furthermore, the results suggest that the effects of risperidone on neuropeptide mRNA levels are fully accounted for by its D2 antagonism and that no indication exists for a role of 5-HT2A receptor blockade in this action.
Negative_regulation (blockade) of 5-HT2A associated with neuropeptide
2) Confidence 0.57 Published 1998 Journal Synapse Section Abstract Doc Link 9517839 Disease Relevance 0 Pain Relevance 0.30
All animals receiving DMI showed significant down-regulation of 5-HT2 receptors except those receiving FLU in combination.
Negative_regulation (regulation) of 5-HT2 associated with desipramine and fluoxetine
3) Confidence 0.57 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8189233 Disease Relevance 0 Pain Relevance 1.18
Consistent with the reduction of 5-HT2A/2C receptors, the adrenocorticotropin response to DOI was attenuated markedly and selectively (-58%; P < .05) in PD70 progeny following prenatal exposure to fluoxetine.
Negative_regulation (reduction) of 5-HT2A associated with fluoxetine
4) Confidence 0.57 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182530 Disease Relevance 0.07 Pain Relevance 0.77
Both drugs similarly decreased the 5-HT2 receptor number on all days of treatment (by about 30 %).
Negative_regulation (decreased) of 5-HT2
5) Confidence 0.42 Published 2007 Journal Inflamm. Res. Section Body Doc Link 17522810 Disease Relevance 0 Pain Relevance 0
It was further found that 5-HT2A/C receptor blockade with ritanserin had only modest effects on preproenkephalin-B and preprotachykinin mRNA levels and did not affect preproenkephalin-A mRNA levels.
Negative_regulation (blockade) of 5-HT2A
6) Confidence 0.42 Published 1998 Journal Synapse Section Abstract Doc Link 9517839 Disease Relevance 0 Pain Relevance 0.34
Fluoxetine, a selective serotonin uptake inhibitor (SSRI) and ketanserin a 5-HT2A antagonist, attenuated PKC translocation by MDMA with differing efficacies; however, both compounds completely prevented the loss of 5-HT uptake sties after multiple doses of MDMA.
Negative_regulation (antagonist) of 5-HT2A associated with kinase c, antagonist, ssri, serotonin and fluoxetine
7) Confidence 0.42 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9272479 Disease Relevance 0 Pain Relevance 0.82
However, if that were the case, it might be expected that blockade of both D1 dopamine receptors and 5-HT2A receptors would be needed in order to produce a complete antagonism of d-amphetamine’s effect on T50.
Negative_regulation (blockade) of 5-HT2A associated with dopamine receptor
8) Confidence 0.42 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2761547 Disease Relevance 0 Pain Relevance 0.28
These responses included hyperglycemia, corticosterone release, and head shakes; cortical 5-HT2 receptor number and DOI-induced prolactin release (a 5-HT1C/5-HT2 receptor-mediated event) were also analyzed.
Negative_regulation (number) of 5-HT2 in head associated with hyperglycemia
9) Confidence 0.42 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8095465 Disease Relevance 0.33 Pain Relevance 0.21
Ipsapirone administration for 21 days reduced fluid intake and decreased body weight, but did not affect baseline plasma glucose, corticosterone, and prolactin levels or cortical 5-HT2 receptor number.
Negative_regulation (number) of 5-HT2 in plasma associated with body weight
10) Confidence 0.42 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8095465 Disease Relevance 0.34 Pain Relevance 0.39
In contrast, at PD70, the maximal density of hypothalamic 5-HT2A/2C receptors was reduced significantly (-35%) in male progeny of fluoxetine-treated dams.
Negative_regulation (reduced) of 5-HT2A associated with fluoxetine
11) Confidence 0.41 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182530 Disease Relevance 0.07 Pain Relevance 0.76
The number of 5-HT2 and 5-HT1A binding sites was decreased: the 5-HT1B binding sites remained unchanged.
Negative_regulation (decreased) of 5-HT2
12) Confidence 0.41 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3780861 Disease Relevance 0.09 Pain Relevance 0.34
Methysergide may act as a neutral antagonist that blocks the effect of inverse agonists on the 5-HT 2A receptor.
Negative_regulation (blocks) of 5-HT 2A associated with antagonist and agonist
13) Confidence 0.41 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16051396 Disease Relevance 0.86 Pain Relevance 0.84
If this inhibitory tone is removed, either by decreasing 5-HT release through activation 5-HT1A autoreceptors or by blocking postsynaptic 5-HT2 receptors, noradrenaline release increases.
Negative_regulation (blocking) of 5-HT2 associated with noradrenaline
14) Confidence 0.41 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7984279 Disease Relevance 0 Pain Relevance 0.42
These data indicate that a 3-week treatment with anxiolytic doses of the 5-HT1A receptor agonist ipsapirone does not desensitize 5-HT2 receptors.
Neg (not) Negative_regulation (desensitize) of 5-HT2 associated with anxiety disorder and agonist
15) Confidence 0.41 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8095465 Disease Relevance 0.36 Pain Relevance 0.38
These results suggest that MDMA increases PKC translocation by two interrelated mechanisms that involve 5-HT2A/2C receptors and the 5-HT transporter.
Negative_regulation (involve) of 5-HT2A associated with kinase c
16) Confidence 0.41 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9272479 Disease Relevance 0 Pain Relevance 0.74
The results are interpreted to indicate that mianserin increases extracellular DA as a result of the concurrent blockade of alpha2 and 5HT2 receptors.
Negative_regulation (blockade) of 5HT2
17) Confidence 0.41 Published 1996 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8741935 Disease Relevance 0 Pain Relevance 0.99
However, the other serotonin receptor antagonist used, metergoline, which blocks both 5-HT1 and 5-HT2 receptor subtypes, attenuated FIA per se but decreased only CAS in apomorphine induced increase in FIA.
Negative_regulation (blocks) of 5-HT2 associated with antagonist, aggression and serotonin
18) Confidence 0.41 Published 1991 Journal Indian J. Exp. Biol. Section Abstract Doc Link 1839019 Disease Relevance 1.13 Pain Relevance 0.63

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