INT165811

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 5.99
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Phc1) DNA binding (Phc1)
Anatomy Link Frequency
nucleus accumbens 1
caudate-putamen 1
olfactory tubercle 1
heart 1
Phc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 458 99.68 Very High Very High Very High
anticonvulsant 1 99.24 Very High Very High Very High
noradrenaline 62 98.48 Very High Very High Very High
Nucleus accumbens 25 96.24 Very High Very High Very High
Bioavailability 2 89.20 High High
Neurotransmitter 33 88.96 High High
drug abuse 14 86.64 High High
headache 16 83.44 Quite High
depression 11 80.28 Quite High
tolerance 3 76.72 Quite High
Disease Link Frequency Relevance Heat
Schizotypal Personality Disorder 1 99.92 Very High Very High Very High
Prehypertension 10 99.84 Very High Very High Very High
Stroke 3 99.36 Very High Very High Very High
Hypertension 69 99.00 Very High Very High Very High
Myocardial Infarction 3 98.92 Very High Very High Very High
Psychosis 12 98.60 Very High Very High Very High
Manic Depressive Disorder 11 98.08 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 677 97.68 Very High Very High Very High
Substance Abuse 19 86.64 High High
Mental Disorders 14 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In subjects with prehypertension, daily intake of both MPH1 and MPH2 did not affect BP.
MPH1 Binding (intake) of associated with prehypertension and hypertension
1) Confidence 0.15 Published 2010 Journal Nutr J Section Body Doc Link PMC2989300 Disease Relevance 0.94 Pain Relevance 0.09
Highest specific MPH binding was found in terminal regions of the nigrostriatal and mesolimbic pathways (caudate-putamen, nucleus accumbens, olfactory tubercle and bed nucleus of the stria terminalis) [52].
MPH Binding (binding) of in nucleus accumbens associated with nucleus accumbens
2) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.13 Pain Relevance 0.54
Indirect support for MPH¬ís noradrenergic actions also comes from the finding that ADHD symptoms can be recreated by blocking ?
MPH Binding (Indirect) of associated with attention deficit hyperactivity disorder
3) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.60 Pain Relevance 0.55
For example, it has been demonstrated that MPH binds to the dopamine transporter and blocks its activity [4].
MPH Binding (binds) of associated with dopamine
4) Confidence 0.05 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2905344 Disease Relevance 0.35 Pain Relevance 0.24
In conclusion, drug-drug interactions with MPH are likely mediated via CES1 inhibition as a result of concomitant drug therapies.
MPH Binding (interactions) of
5) Confidence 0.05 Published 2010 Journal Toxicology Section Abstract Doc Link 20097249 Disease Relevance 0 Pain Relevance 0.07
Children with the s's' genotype responded significantly better to placebo and did not derive a further improvement with MPH.
MPH Neg (not) Binding (improvement) of
6) Confidence 0.04 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2905344 Disease Relevance 0.06 Pain Relevance 0.07
Indeed, children with the l'l' genotype retained clinically significant impairment after treatment with placebo (CGI-Parents>65) and improved to the non-clinical range with MPH.
MPH Binding (range) of
7) Confidence 0.04 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2905344 Disease Relevance 0.08 Pain Relevance 0.03
On the other hand, we did not identify a genotype or genotype-by-treatment interaction with therapeutic response to MPH as assessed by teachers in the school environment.
MPH Neg (not) Binding (interaction) of
8) Confidence 0.04 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2905344 Disease Relevance 0.14 Pain Relevance 0
Under the assumption that 5-HT transmission may be part of the biological mechanisms mediating behavioral response to MPH, we have examined the association of the polymorphic 5-HTTLPR with behavioral response to MPH by using a double-blind, placebo-controlled crossover study to test this association.


MPH Spec (examined) Binding (association) of
9) Confidence 0.04 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2905344 Disease Relevance 0.37 Pain Relevance 0
Larger effect sizes (1.3, P < 0.02) were associated with physician ratings of outcomes and larger doses of MPH (0.9 mg/kg/day or higher).53
MPH Binding (associated) of
10) Confidence 0.03 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732009 Disease Relevance 0.50 Pain Relevance 0.04
Highest specific MPH binding was found in terminal regions of the nigrostriatal and mesolimbic pathways (caudate-putamen, nucleus accumbens, olfactory tubercle and bed nucleus of the stria terminalis) [52].
MPH Binding (binding) of in olfactory tubercle associated with nucleus accumbens
11) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.13 Pain Relevance 0.54
Highest specific MPH binding was found in terminal regions of the nigrostriatal and mesolimbic pathways (caudate-putamen, nucleus accumbens, olfactory tubercle and bed nucleus of the stria terminalis) [52].
MPH Binding (binding) of in caudate-putamen associated with nucleus accumbens
12) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.13 Pain Relevance 0.54
Interaction between MPH products and some anticonvulsants, including phenobarbital, phenytoin, and ethosuximide may occur.
MPH Binding (Interaction) of associated with anticonvulsant
13) Confidence 0.02 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695228 Disease Relevance 1.19 Pain Relevance 0.28
The patient medication guide for MPH preparations includes a warning that MPH has been associated with a risk of stroke and heart attack in adults.
MPH Binding (associated) of in heart associated with stroke and myocardial infarction
14) Confidence 0.00 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697545 Disease Relevance 1.36 Pain Relevance 0.12

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