INT165821

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 27
Total Number 34
Disease Relevance 24.37
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
eyes 4
B cells 4
astrocytes 4
brains 3
cerebrospinal fluid 2
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 802 100.00 Very High Very High Very High
Inflammation 221 99.68 Very High Very High Very High
ischemia 61 99.44 Very High Very High Very High
glial activation 3 98.76 Very High Very High Very High
Inflammatory mediators 13 98.16 Very High Very High Very High
Spinal cord 364 97.76 Very High Very High Very High
cva 76 90.68 High High
cytokine 66 90.68 High High
substantia gelatinosa 13 83.12 Quite High
tolerance 39 82.88 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 2807 99.84 Very High Very High Very High
Myopia 191 99.76 Very High Very High Very High
INFLAMMATION 234 99.68 Very High Very High Very High
Autoimmune Disease 289 99.54 Very High Very High Very High
Cv Unclassified Under Development 38 99.44 Very High Very High Very High
Ocular Hypertension 238 99.24 Very High Very High Very High
Hypertrophy 26 99.20 Very High Very High Very High
Stress 20 99.02 Very High Very High Very High
Hypoxia 19 98.96 Very High Very High Very High
Infection 247 98.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed increase in AQP4 levels seen at 2 weeks in this study are likely due to de novo AQP4 synthesis, as AQP4 mRNA is significantly upregulated in hydrocephalic rat brains [18].
Positive_regulation (upregulated) of AQP4 mRNA in brains
1) Confidence 0.70 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.58 Pain Relevance 0
These observations suggest that IOP elevation is an important factor for increasing the levels of AQP4 and GFAP, which could promote glial activation at the optic nerve.
Positive_regulation (increasing) of AQP4 in optic nerve associated with ocular hypertension and glial activation
2) Confidence 0.68 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.24 Pain Relevance 0.05
Whether the upregulation of AQP4 explains astrocyte hypertrophy in the ONH is not clear and may require a selective AQP4 knockout in ON astrocytes.
Spec (Whether) Positive_regulation (upregulation) of AQP4 in astrocytes associated with targeted disruption and hypertrophy
3) Confidence 0.68 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.64 Pain Relevance 0.11
No significant differences were seen in the level of AQP4 expression in the IPL, suggesting that AQP4 upregulation only occurs at the endfeet of Müller cells at the vitreal border in growing eyes.


Positive_regulation (upregulation) of AQP4 in eyes
4) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.67 Pain Relevance 0
As AQPs are known to facilitate transcellular water movement in response to osmolarity changes [42,43], the AQP4 upregulation observed during the induction of myopia in the present study is consistent with previously described changes to ion and water distribution patterns in FDM [25,26].
Positive_regulation (upregulation) of AQP4 associated with myopia
5) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.74 Pain Relevance 0
There was a significant increase of brain water content and of aquaporin-4 levels in the P3 group.
Positive_regulation (increase) of aquaporin-4 in brain
6) Confidence 0.66 Published 2010 Journal Anesthesiology Section Body Doc Link 20098129 Disease Relevance 0.17 Pain Relevance 0
The pattern of upregulation of AQP4expression in fellow eyes was similar to that described in the experimental eyes though not as pronounced.
Positive_regulation (upregulation) of AQP4expression in eyes
7) Confidence 0.61 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.08 Pain Relevance 0
It seems reasonable to hypothesize that AQP4 specific T cells are present in patients with NMO-IgG as AQP4 is a protein antigen that requires T cell help for induction of AQP4-specific B cells.
Positive_regulation (induction) of AQP4 in B cells associated with neuromyelitis optica
8) Confidence 0.57 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.08 Pain Relevance 0.19
-lysophosphatidylcholine stearoyl (LPS), ventriculomegaly was correlated to increased AQP4 in astrocytes residing in periventricular areas such as in corpus callosum [17].
Positive_regulation (increased) of AQP4 in astrocytes
9) Confidence 0.50 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.72 Pain Relevance 0
At two weeks, increased abundance of AQP4 expressed in astrocyte processes of the periventricular region was found, together with significant elevated ADC values.
Positive_regulation (abundance) of AQP4 in astrocyte
10) Confidence 0.50 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.80 Pain Relevance 0.25
The observed increase in AQP4 levels seen at 2 weeks in this study are likely due to de novo AQP4 synthesis, as AQP4 mRNA is significantly upregulated in hydrocephalic rat brains [18].
Positive_regulation (increase) of AQP4 in brains
11) Confidence 0.50 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.58 Pain Relevance 0
Such an increase in AQP4 channels at the vitreo-retinal border would support enhanced water movement from the inner retina to the vitreous cavity via the Müller cells [11].
Positive_regulation (increase) of AQP4 in retina
12) Confidence 0.48 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.75 Pain Relevance 0
Figure 2B shows parallel changes in AQP4 mRNA to protein levels.
Positive_regulation (changes) of AQP4
13) Confidence 0.48 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.31 Pain Relevance 0.04
The water channel protein aquaporin-4 (AQP4) is reported to be of possible major importance for accessory cerebrospinal fluid (CSF) circulation pathways.
Spec (possible) Positive_regulation (importance) of AQP4 in cerebrospinal fluid
14) Confidence 0.47 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2987763 Disease Relevance 0.24 Pain Relevance 0.07
The water channel protein aquaporin-4 (AQP4) is reported to be of possible major importance for accessory cerebrospinal fluid (CSF) circulation pathways.
Spec (possible) Positive_regulation (importance) of aquaporin-4 in cerebrospinal fluid
15) Confidence 0.47 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2987763 Disease Relevance 0.24 Pain Relevance 0.07
Although there was a trend toward upregulation of AQP4 labeling in the IPL in FD eyes as opposed to fellow eyes, this was not significant, indicating that the majority of upregulation of AQP4 was predominantly at the vitreal border.


Positive_regulation (upregulation) of AQP4 in eyes
16) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.07 Pain Relevance 0
Although there was a trend toward upregulation of AQP4 labeling in the IPL in FD eyes as opposed to fellow eyes, this was not significant, indicating that the majority of upregulation of AQP4 was predominantly at the vitreal border.


Positive_regulation (upregulation) of AQP4 in eyes
17) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.07 Pain Relevance 0
By contrast, AQP4 increased in ONH astrocytes, a mechanism that may involve alterations of the ubiquitin-dependent proteasomal activities.
Positive_regulation (increased) of AQP4 in astrocytes
18) Confidence 0.45 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.73 Pain Relevance 0.03
As expected from our earlier studies that demonstrated upregulated AQP4 channel expression during form-deprivation myopia (FDM) [15], the elevation of AQP4 at the vitreo-retinal border during minus lens-induced myopic development was also seen here.
Positive_regulation (elevation) of AQP4 in lens associated with myopia
19) Confidence 0.45 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.66 Pain Relevance 0
However, the sites of greatest expression and the temporal pattern of the upregulation of AQP4 and Kir4.1 were dissimilar, indicating a dissociation of AQP4 and Kir4.1 function during refractive error development.
Positive_regulation (upregulation) of AQP4 associated with refractive errors
20) Confidence 0.45 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927440 Disease Relevance 0.41 Pain Relevance 0

General Comments

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