INT165853

Context Info Confidence 0.37 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.33 Pain Relevance 0.30

cytoplasm (Il13, Nfkb1) mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)

Anatomy Link Frequency PSCs 2 Il13 (Rattus norvegicus) Nfkb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 2 86.08 Inflammation 1 85.68 Chronic pancreatitis 2 74.76 fibrosis 1 67.92

Disease Link Frequency Relevance Heat Fibrosis 3 90.08 INFLAMMATION 1 85.68 Pancreatitis 2 74.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IL-13 inhibited the transcriptional activity of NF-kappaB, and the expression of mutant I-kappaB reproduced the suppression of autocrine TGF-beta(1) and promoted PSCs proliferation.

IL-13 Negative_regulation (inhibited) of Transcription (activity) of NF-kappaB in PSCs

1) Confidence 0.37 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20100461 Disease Relevance 0.33 Pain Relevance 0.30

General Comments

This test has worked.