INT16588

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 4.76
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
plasma 10
brain 4
blood 2
pituitary gland 2
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 25 99.54 Very High Very High Very High
Dopamine 8 98.72 Very High Very High Very High
narcan 9 98.22 Very High Very High Very High
Migraine 2 91.12 High High
antagonist 2 90.40 High High
isoflurane 2 87.92 High High
Catecholamine 8 86.76 High High
ketamine 3 85.48 High High
agonist 5 81.04 Quite High
anesthesia 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 21 99.32 Very High Very High Very High
Hyperinsulinism 1 98.32 Very High Very High Very High
Cancer 1 97.64 Very High Very High Very High
Hyperlipidemia 1 96.88 Very High Very High Very High
Hyperglycemia 8 95.88 Very High Very High Very High
Obesity 16 93.84 High High
Depression 1 91.40 High High
Headache 2 91.12 High High
Psychosis 2 90.08 High High
Schizophrenia 1 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apomorphine did not produce a statistically significant increase in plasma growth hormone concentration when administered directly into the the third ventricle, and pimozide failed to abolish the increase in plasma growth hormone produced by L-dopa.
Positive_regulation (increase) of Gene_expression (produced) of plasma growth hormone in plasma
1) Confidence 0.62 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.33
Arginine has been used by millions of athletes over the past 20 years to enhance production of human growth hormone.
Positive_regulation (enhance) of Gene_expression (production) of growth hormone
2) Confidence 0.60 Published 2004 Journal Turk J Gastroenterol Section Abstract Doc Link 15264124 Disease Relevance 0.27 Pain Relevance 0.06
The increase in plasma growth hormone concentration produced by intravenous L-dopa and clonidine was prevented by administration of phentolamine or phenoxybenzamine directly into the third ventricle.
Positive_regulation (increase) of Gene_expression (produced) of plasma growth hormone in plasma associated with clonidine
3) Confidence 0.42 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.36
The data indicate that in pentobarbital anesthetized dogs, the increase in growth hormone secretion produced by L-dopa is mediated by norepinephrine, rather than dopamine, that the site of action of the norepinephrine is central, above the median eminence and inside the 'blood-brain barrier', and that the norepinephrine acts via alpha-adrenergic receptors.
Positive_regulation (mediated) of Gene_expression (produced) of growth hormone in brain associated with dopamine
4) Confidence 0.42 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.28
The data indicate that in pentobarbital anesthetized dogs, the increase in growth hormone secretion produced by L-dopa is mediated by norepinephrine, rather than dopamine, that the site of action of the norepinephrine is central, above the median eminence and inside the 'blood-brain barrier', and that the norepinephrine acts via alpha-adrenergic receptors.
Positive_regulation (increase) of Gene_expression (produced) of growth hormone in brain associated with dopamine
5) Confidence 0.42 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.28
Naloxone treatment caused reduction of blood ACTH, corticosterone, and beta endorphin levels but elevated growth hormone levels.
Positive_regulation (elevated) of Gene_expression (levels) of growth hormone in blood associated with narcan
6) Confidence 0.26 Published 1985 Journal Int J Obes Section Abstract Doc Link 2993179 Disease Relevance 1.71 Pain Relevance 0.41
The acute hyperglycemic effect of KX in fed rats was associated with decreased plasma levels of insulin, adrenocorticotropic hormone (ACTH), and corticosterone and increased levels of glucagon and growth hormone (GH).
Positive_regulation (increased) of Gene_expression (levels) of growth hormone in plasma
7) Confidence 0.23 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16246906 Disease Relevance 0.55 Pain Relevance 0.32
The data suggest that collagen accumulation in diabetic myocardium does not appear to be dependent on increased plasma levels of growth hormone, but a role for enhanced sensitivity to hormonal action is not excluded.
Positive_regulation (increased) of Gene_expression (levels) of growth hormone in plasma associated with diabetes mellitus
8) Confidence 0.22 Published 1987 Journal J. Lab. Clin. Med. Section Abstract Doc Link 3611950 Disease Relevance 0.58 Pain Relevance 0.24
Relation of growth hormone and myocardial collagen accumulation in experimental diabetes.
Positive_regulation (accumulation) of Gene_expression (Relation) of growth hormone associated with diabetes mellitus
9) Confidence 0.20 Published 1987 Journal J. Lab. Clin. Med. Section Title Doc Link 3611950 Disease Relevance 0.72 Pain Relevance 0.13
Increased plasma levels of growth hormone, insulin-like growth factor (IGF)-I and IGF-binding protein 3 in pregnant rats with exercise.
Positive_regulation (Increased) of Gene_expression (levels) of growth hormone in plasma
10) Confidence 0.20 Published 2006 Journal Tohoku J. Exp. Med. Section Title Doc Link 16340176 Disease Relevance 0.08 Pain Relevance 0.06
The proportion of growth hormone deficiencies thus varies considerably according to the test used.
Positive_regulation (proportion) of Gene_expression (deficiencies) of growth hormone
11) Confidence 0.15 Published 1993 Journal Acta Paediatr. Section Abstract Doc Link 8495077 Disease Relevance 0 Pain Relevance 0.14
The treatment did not modify basal prolactin and growth hormone levels, but prolactin response to thyrotropin releasing hormone was enhanced.
Positive_regulation (enhanced) of Gene_expression (levels) of growth hormone
12) Confidence 0.05 Published 1990 Journal Cephalalgia Section Abstract Doc Link 2107977 Disease Relevance 0.25 Pain Relevance 0.21
Comparison with a previous placebo test performed in a subgroup of 92 subjects (46 MDEs, 20 SCZs, 8 SADs, and 18 HCs) showed that CLO induced a significant increase of growth hormone, prolactin (PRL) and thyrotropin (TSH) levels but no significant change in adrenocorticotropin and cortisol release.
Positive_regulation (increase) of Gene_expression (levels) of growth hormone associated with clonidine
13) Confidence 0.01 Published 2000 Journal Psychoneuroendocrinology Section Abstract Doc Link 10938452 Disease Relevance 0.51 Pain Relevance 0.46
Chronic overproduction of growth hormone in man and the cat is most often caused by a GH-producing tumour of the pituitary gland.
Positive_regulation (overproduction) of Gene_expression (overproduction) of growth hormone in pituitary gland associated with cancer
14) Confidence 0.01 Published 1991 Journal Acta Endocrinol. Section Abstract Doc Link 1839344 Disease Relevance 0.10 Pain Relevance 0.09

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