INT165891

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 7.63
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
retina 1
spinal cord 1
pituitary 1
lobe 1
optic nerve 1
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 60 99.20 Very High Very High Very High
Spinal cord 56 99.12 Very High Very High Very High
Central nervous system 184 99.08 Very High Very High Very High
depression 56 98.24 Very High Very High Very High
Paracetamol 14 94.32 High High
cytokine 188 94.04 High High
Inflammation 178 94.04 High High
Brush evoked pain 8 93.60 High High
ketamine 12 84.56 Quite High
Hippocampus 64 84.44 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 128 99.20 Very High Very High Very High
Neurodegenerative Disease 42 98.60 Very High Very High Very High
Depression 56 98.24 Very High Very High Very High
Disease 246 98.12 Very High Very High Very High
Stress 90 97.96 Very High Very High Very High
Hepatitis 4 95.04 Very High Very High Very High
INFLAMMATION 214 94.04 High High
Neuropathic Pain 8 93.60 High High
Nervous System Injury 24 87.52 High High
Schizophrenia 24 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-18 mRNA expression is elevated in subordinate rat models with depression with respect to dominant rats [133].
Transcription (expression) of IL-18 associated with depression
1) Confidence 0.69 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.90 Pain Relevance 0.61
Elevated IL-18 transcript was found at the onset and throughout the course of the disease.
Transcription (found) of IL-18 associated with disease
2) Confidence 0.69 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.50 Pain Relevance 0.63
At the same time it was demonstrated that the truncated decoy form of the IL-18R?
Transcription (form) of IL-18R
3) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.23 Pain Relevance 0.26
Interestingly, the genes encoding for IL-18 and its receptors are subject to differential promoter usage and their transcription to differential splicing indicating that these molecules have the potential of being produced in a tissue/cell specific way in response to different stimuli [26,78].
Transcription (transcription) of IL-18
4) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.18 Pain Relevance 0.19
They include a short transcript for IL-18R?
Transcription (transcript) of IL-18R
5) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0 Pain Relevance 0.09
In this respect, stress has been shown to induce transient IL-18 mRNA elevation in rat pituitary cells where increase of the IL-18 mRNA level was observed also after adrenalectomy [57].
Transcription (level) of IL-18 in pituitary associated with stress
6) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.45 Pain Relevance 0.19
High levels of IL-18 mRNA were found in the brain and the spinal cord of rats with experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS) [89,90].
Transcription (found) of IL-18 in spinal cord associated with multiple sclerosis and spinal cord
7) Confidence 0.51 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.43 Pain Relevance 0.66
For instance, the levels of IL-18 transcript and protein were increased in the frontal lobe of AD patients compared to healthy age-matched controls.
Transcription (transcript) of IL-18 in lobe associated with disease
8) Confidence 0.51 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.55 Pain Relevance 0.36
By RT–PCR, mRNA and protein expression of both TNF and IL-18 were significantly reduced in the retina and optic nerve of AAV-PEDF transfected mice as compared to AAV-GFP mice (Figure 8A-F), suggesting an anti-inflammatory effect of PEDF in the DBA/2J mice.


Transcription (expression) of IL-18 in optic nerve associated with inflammation
9) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.32 Pain Relevance 0.09
The significant increase of GOT and GPT activities was found to be accompanied with the elevation of hepatic TBARS level, IL-18 mRNA expression and serum IL-18 concentration, and was significantly alleviated by supplementation with 6 % S. platensis in diets.
Transcription (expression) of IL-18
10) Confidence 0.29 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 20102673 Disease Relevance 0.37 Pain Relevance 0.60
The significant increase of GOT and GPT activities was found to be accompanied with the elevation of hepatic TBARS level, IL-18 mRNA expression and serum IL-18 concentration, and was significantly alleviated by supplementation with 6 % S. platensis in diets.
Transcription (expression) of IL-18
11) Confidence 0.22 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 20102673 Disease Relevance 0.37 Pain Relevance 0.60
By RT–PCR, mRNA and protein expression of both TNF and IL-18 were significantly reduced in the retina and optic nerve of AAV-PEDF transfected mice as compared to AAV-GFP mice (Figure 8A-F), suggesting an anti-inflammatory effect of PEDF in the DBA/2J mice.


Transcription (expression) of IL-18 in retina associated with inflammation
12) Confidence 0.17 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.32 Pain Relevance 0.09

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