INT165892

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Context Info
Confidence 0.66
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.72
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
pituitary 2
lobe 2
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 21 98.72 Very High Very High Very High
Paracetamol 14 95.68 Very High Very High Very High
cytokine 69 94.04 High High
Inflammation 54 91.44 High High
Central nervous system 69 88.00 High High
ketamine 3 84.56 Quite High
Glutamate 7 82.16 Quite High
antidepressant 3 79.92 Quite High
Dopamine 3 78.64 Quite High
antagonist 3 77.92 Quite High
Disease Link Frequency Relevance Heat
Disease 90 99.04 Very High Very High Very High
Depression 21 98.72 Very High Very High Very High
Stress 33 98.28 Very High Very High Very High
Hepatitis 4 96.40 Very High Very High Very High
INFLAMMATION 66 91.44 High High
Alzheimer's Dementia 9 86.24 High High
Schizophrenia 9 85.48 High High
Amyloid Plaque 3 76.96 Quite High
Injury 7 75.00 Quite High
Body Weight 4 73.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-18 mRNA expression is elevated in subordinate rat models with depression with respect to dominant rats [133].
Positive_regulation (elevated) of Transcription (expression) of IL-18 associated with depression
1) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.90 Pain Relevance 0.61
In this respect, stress has been shown to induce transient IL-18 mRNA elevation in rat pituitary cells where increase of the IL-18 mRNA level was observed also after adrenalectomy [57].
Positive_regulation (increase) of Transcription (level) of IL-18 in pituitary associated with stress
2) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.46 Pain Relevance 0.19
For instance, the levels of IL-18 transcript and protein were increased in the frontal lobe of AD patients compared to healthy age-matched controls.
Positive_regulation (increased) of Transcription (transcript) of IL-18 in lobe associated with disease
3) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.61 Pain Relevance 0.37
The significant increase of GOT and GPT activities was found to be accompanied with the elevation of hepatic TBARS level, IL-18 mRNA expression and serum IL-18 concentration, and was significantly alleviated by supplementation with 6 % S. platensis in diets.
Positive_regulation (elevation) of Transcription (expression) of IL-18
4) Confidence 0.21 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 20102673 Disease Relevance 0.37 Pain Relevance 0.61
The significant increase of GOT and GPT activities was found to be accompanied with the elevation of hepatic TBARS level, IL-18 mRNA expression and serum IL-18 concentration, and was significantly alleviated by supplementation with 6 % S. platensis in diets.
Positive_regulation (elevation) of Transcription (expression) of IL-18
5) Confidence 0.19 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 20102673 Disease Relevance 0.37 Pain Relevance 0.61

General Comments

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