INT165911

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 7.94
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
joints 1
muscle 1
proximal 1
fat cells 1
T cell 1
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 231 99.80 Very High Very High Very High
rheumatoid arthritis 101 99.72 Very High Very High Very High
Kinase C 81 99.44 Very High Very High Very High
cytokine 239 97.76 Very High Very High Very High
Clonidine 26 96.80 Very High Very High Very High
Arthritis 247 93.44 High High
Inflammatory response 60 92.68 High High
tolerance 92 83.68 Quite High
Central nervous system 14 65.36 Quite High
antagonist 41 63.60 Quite High
Disease Link Frequency Relevance Heat
Obesity 101 100.00 Very High Very High Very High
INFLAMMATION 296 99.80 Very High Very High Very High
Rheumatoid Arthritis 101 99.72 Very High Very High Very High
Apoptosis 14 99.48 Very High Very High Very High
Targeted Disruption 155 99.02 Very High Very High Very High
Sprains And Strains 23 98.96 Very High Very High Very High
Pressure And Volume Under Development 82 95.20 Very High Very High Very High
Disease 194 94.56 High High
Arthritis 262 93.44 High High
Hypersensitivity 36 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, our data show that PDE4 inhibition resolves neutrophilic inflammation by promoting caspase-dependent apoptosis of inflammatory cells by targeting a PKA/PI3K/Akt-dependent survival pathway.
Localization (targeting) of PI3K associated with inflammation and apoptosis
1) Confidence 0.51 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.74 Pain Relevance 0.21
The present study demonstrates that resistance exercise does not alter the activity of the IGF-1 receptor or result in recruitment of PI3K to IRS1/2.
Localization (recruitment) of PI3K
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.15 Pain Relevance 0
Thus, influence of PI3K?
Localization (influence) of PI3K
3) Confidence 0.29 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.29 Pain Relevance 0.62
No differences between the strains could be detected, again pointing to normal T cell responses in the PI3K?
Localization (responses) of PI3K in T cell associated with sprains and strains
4) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.83 Pain Relevance 0.20
Cells stimulated with mBSA did not secrete detectable quantities of this cytokine (data not shown), while after activation with anti-CD3-antibodies comparable amounts of IL-17 were produced by wildtype and PI3K?
Localization (wildtype) of PI3K associated with cytokine
5) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.87 Pain Relevance 0.24
Finally, immunohistochemical analysis of inflamed joints revealed a markedly reduced infiltration of PI3K?
Localization (infiltration) of PI3K in joints
6) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.55 Pain Relevance 0.15
Recent studies provide further support for PI3K as a modulator of APP trafficking and demonstrate that over-activation of the insulin/IGF-1 signaling pathway may result in feedback inhibition of PI3K through IRS1 and reduced APP trafficking and A ?
Localization (support) of PI3K
7) Confidence 0.24 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.79 Pain Relevance 0.03
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Localization (translocation) of PI3K in fat cells associated with kinase c and obesity
8) Confidence 0.23 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10
-knockout mice are resistant to models of RA and that the administration of PI3K?
Localization (administration) of PI3K associated with targeted disruption and rheumatoid arthritis
9) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.84 Pain Relevance 0.38
, a specific substrate of PI3K?
Localization (substrate) of PI3K
10) Confidence 0.15 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.77
CD14 deficiency results in increased localization of PI3K to lipid rafts, hyperphosphorylation of AKT, and reduced activation of p38.
Localization (localization) of PI3K
11) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2781632 Disease Relevance 0.47 Pain Relevance 0.31
We found that following activation by B. burgdorferi, significantly more PI3K is recruited to the lipid rafts of M?
Localization (more) of PI3K
12) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0
We found that following activation by B. burgdorferi, significantly more PI3K is recruited to the lipid rafts of M?
Localization (recruited) of PI3K
13) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0
These data suggest that regulated localization of PI3K (and likely other molecules) to B. burgdorferi-induced lipid rafts links proximal membrane events to distal intracellular signaling cascades.


Localization (localization) of PI3K in proximal
14) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.07 Pain Relevance 0.10
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Localization (translocation) of PI3K in muscle associated with kinase c and obesity
15) Confidence 0.08 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10
The site-directed mutations at residues 315 and 322 interfere with the recruitment of the p85 subunit of PI3-K [16], and thereby PI3-K is not recruited and activated.
Neg (not) Localization (recruited) of PI3-K
16) Confidence 0.06 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.01 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox