INT165914

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
neutrophil 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 9 89.92 High High
Glutamate 1 77.52 Quite High
antagonist 1 73.24 Quite High
Paracetamol 1 72.80 Quite High
cINOD 1 43.68 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 2 99.96 Very High Very High Very High
Apoptosis 6 95.60 Very High Very High Very High
Stress 5 89.24 High High
INFLAMMATION 7 88.48 High High
Injury 1 44.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While RNAi depletion of Keap1 led to reduced toxicity following exposure to DNCB, depletion of Nrf2 and NF-kappaB augmented toxicity.
Positive_regulation (augmented) of Negative_regulation (depletion) of NF-kappaB associated with toxicity
1) Confidence 0.48 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.48 Pain Relevance 0.11
Although LPS induced NF-kappaB activation, which was blocked by rolipram, NF-kappaB inhibitors did not promote resolution of neutrophil accumulation in this model.
Neg (not) Positive_regulation (promote) of Negative_regulation (inhibitors) of NF-kappaB in neutrophil
2) Confidence 0.35 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.53 Pain Relevance 0.23

General Comments

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