INT165915

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 6.72
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
pleural cavity 2
lung 2
neutrophils 2
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 53 99.84 Very High Very High Very High
fibrosis 238 99.56 Very High Very High Very High
Inflammation 333 99.48 Very High Very High Very High
cytokine 136 97.72 Very High Very High Very High
Inflammatory response 32 96.80 Very High Very High Very High
cINOD 5 94.28 High High
Glutamate 3 87.84 High High
rheumatoid arthritis 34 77.00 Quite High
headache 3 76.08 Quite High
Arthritis 22 66.72 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 103 99.56 Very High Very High Very High
INFLAMMATION 349 99.48 Very High Very High Very High
Pulmonary Disease 161 99.16 Very High Very High Very High
Pulmonary Fibrosis 140 99.00 Very High Very High Very High
Apoptosis 13 98.00 Very High Very High Very High
Pneumonia 39 93.76 High High
Granuloma 60 92.24 High High
Colitis 5 87.52 High High
Hypersensitivity 15 78.44 Quite High
Disease 42 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of PDE4 inhibition on lung collagen content and remodeling markers
Regulation (Effect) of Negative_regulation (inhibition) of PDE4 in lung
1) Confidence 0.29 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.40 Pain Relevance 0.20
Most research has been aimed at the effects of PDE4 inhibition on LTP.
Regulation (effects) of Negative_regulation (inhibition) of PDE4 associated with long-term potentiation
2) Confidence 0.25 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.33
Based on our observations and the results of other authors we suppose that inhibition of PDE4 affects both general aspects of PF, namely inflammation and tissue remodeling itself.
Regulation (affects) of Negative_regulation (inhibition) of PDE4 associated with fibrosis and inflammation
3) Confidence 0.21 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.02 Pain Relevance 0.47
Effect of PDE4 inhibition on alveolar inflammatory cells content
Regulation (Effect) of Negative_regulation (inhibition) of PDE4 associated with inflammation
4) Confidence 0.21 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.41 Pain Relevance 0.20
The aim of the study was, therefore, to investigate the effects of selective PDE4 inhibitor on different aspects of experimental PF in vivo.


Spec (investigate) Regulation (effects) of Spec (investigate) Negative_regulation (inhibitor) of PDE4 associated with fibrosis
5) Confidence 0.13 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.54 Pain Relevance 0.20
For instance, one study showed differential effect of several PDE4 inhibitors on neutrophils and TNF-a release, indeed revealing some limitations of cilomilast [20].
Regulation (effect) of Negative_regulation (inhibitors) of PDE4 in neutrophils
6) Confidence 0.13 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.70 Pain Relevance 0.39
Here, we examined the effects of specific PDE4 inhibition on the resolution of neutrophilic inflammation in the pleural cavity of LPS-challenged mice.
Spec (examined) Regulation (effects) of Spec (examined) Negative_regulation (inhibition) of PDE4 in pleural cavity associated with inflammation
7) Confidence 0.09 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.60 Pain Relevance 0.26
Phosphodiesterase 4 (PDE4) inhibitors are key
Regulation (key) of Negative_regulation (inhibitors) of PDE4
8) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 1.66 Pain Relevance 0.42
effects of PDE4 inhibitors on Th2
Regulation (effects) of Negative_regulation (inhibitors) of PDE4
9) Confidence 0.03 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 0.14 Pain Relevance 0.10
In contrast to steroids that have a limited anti-inflammatory efficacy in cigarette smoke models both in the mouse and guinea pig, there are increasing numbers of studies documenting the in vivo efficacy of PDE4 inhibitor in animal models of COPD.
Regulation (efficacy) of Negative_regulation (inhibitor) of PDE4 associated with pulmonary disease and inflammation
10) Confidence 0.00 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.25 Pain Relevance 0.35

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