INT165916

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.41
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
cleavage 2
hearts 2
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 93.76 High High
antagonist 1 91.64 High High
cINOD 1 62.08 Quite High
ischemia 12 54.24 Quite High
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 10 99.96 Very High Very High Very High
Diabetes Mellitus 152 99.28 Very High Very High Very High
INFLAMMATION 10 93.76 High High
Myeloid Leukemia 25 93.56 High High
Injury 25 93.24 High High
Targeted Disruption 55 89.28 High High
Cv Unclassified Under Development 12 54.24 Quite High
Myocardial Infarction 4 45.80 Quite Low
Stress 8 5.00 Very Low Very Low Very Low
Hyperglycemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proapoptotic effect of rolipram was associated with decreased levels of the prosurvival protein Mcl-1 and increased caspase-3 cleavage.
Negative_regulation (decreased) of Localization (cleavage) of caspase-3 in cleavage
1) Confidence 0.41 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.77 Pain Relevance 0.31
Furthermore, key markers of apoptosis, caspase-3 activity and cytochrome c release, were reduced in the hearts of diabetic RAGE-modified mice compared with wild-type diabetic littermates in I/R.
Negative_regulation (reduced) of Localization (release) of caspase-3 in hearts associated with diabetes mellitus and apoptosis
2) Confidence 0.09 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453611 Disease Relevance 1.64 Pain Relevance 0.03

General Comments

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