INT165917

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.35
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mcl1) mitochondrion (Mcl1) nucleus (Mcl1)
cytoplasm (Mcl1)
Anatomy Link Frequency
cleavage 2
Mcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 91.64 High High
Inflammation 9 91.12 High High
chemokine 21 68.80 Quite High
cINOD 1 62.08 Quite High
imagery 4 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 52 97.56 Very High Very High Very High
INFLAMMATION 7 91.12 High High
Carcinoma 25 50.84 Quite High
Colon Cancer 25 50.00 Quite Low
Death 7 39.68 Quite Low
Adhesions 35 13.52 Low Low
Metastasis 25 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
Repression 5 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proapoptotic effect of rolipram was associated with decreased levels of the prosurvival protein Mcl-1 and increased caspase-3 cleavage.
Negative_regulation (decreased) of Gene_expression (levels) of Mcl-1 in cleavage
1) Confidence 0.23 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.77 Pain Relevance 0.29
As shown in Figure 4D, immunoblot analysis showed a marked loss of Mcl-1 and Bcl-2 expression coincident with the marked increase in Bim protein levels in anoikis sensitive CXCL12- expressing cells.
Negative_regulation (loss) of Gene_expression (expression) of Mcl-1
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.58 Pain Relevance 0.03

General Comments

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