INT165978

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.78
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD55) plasma membrane (CD55)
Anatomy Link Frequency
platelets 1
head 1
CD55 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 75.48 Quite High
cva 18 59.20 Quite High
Pain 7 50.00 Quite Low
alcohol 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
mu opioid receptor 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemolysis 55 99.92 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 158 93.12 High High
Lifespan 2 93.08 High High
INFLAMMATION 21 75.48 Quite High
Infection 8 74.84 Quite High
Disease 39 67.68 Quite High
Bacterial Infection 2 65.64 Quite High
Cv General 3 Under Development 16 59.20 Quite High
Corneal Disease 4 59.12 Quite High
Communicable Diseases 1 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Common to these methodologies, assessment of CROM is carried out by instructing subjects to move their head as far as possible.
Localization (assessment) of CROM in head
1) Confidence 0.60 Published 2010 Journal Spine Section Body Doc Link 20110842 Disease Relevance 0 Pain Relevance 0
The nucleotide position is fairly conserved in mammals (GERP score: -0.81) but has been subject to selection in humans as apparent from the high derived allele frequency (DAF ?
Localization (selection) of DAF
2) Confidence 0.41 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2587479 Disease Relevance 0 Pain Relevance 0
These bacteria produce phospholipase and other enzymes which can remove GPI-anchored DAF and CD59 from the corneal surface [51].
Localization (anchored) of DAF
3) Confidence 0.40 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.63 Pain Relevance 0.04
We identified the evolutionary trends associated with each cluster by considering the patterns of constraints on polymorphic base positions from the GERP-DAF distribution as well as the GERP distribution of all coding positions, and information available from the literature, as discussed below.
Localization (distribution) of DAF
4) Confidence 0.39 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2587479 Disease Relevance 0 Pain Relevance 0
CD55 and CD59 are deficient on RBCs, but also on white blood cells (WBCs) and platelets (Nicholson-Weller et al 1985); however, as far as WBCs are concerned, there is no evidence of reduced leukocyte lifespan in PNH patients, probably because nucleated cells have an additional transmembrane (ie, non GPI-linked) complement inhibitor (CD46) (Christmas et al 2006).
Localization (deficient) of CD55 in platelets associated with lifespan and paroxysmal nocturnal hemoglobinuria
5) Confidence 0.27 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.15 Pain Relevance 0.06

General Comments

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