INT165981

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.17
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (UGT1A3) enzyme binding (UGT1A3)
UGT1A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endep 12 100.00 Very High Very High Very High
Buprenorphine 14 99.98 Very High Very High Very High
depression 2 91.20 High High
Lamotrigine 2 81.48 Quite High
Nortriptyline 2 80.96 Quite High
Disease Link Frequency Relevance Heat
Respiratory Failure 2 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amitriptyline and temazepam are inhibitors of NBUP glucuronidation (UGT1A3, HLMs), whereas BUP glucuronidation was affected by amitriptyline (HLMs), oxazepam, and temazepam (UGT2B7).
Negative_regulation (inhibitors) of UGT1A3 associated with endep and buprenorphine
1) Confidence 0.58 Published 2010 Journal Int. J. Legal Med. Section Abstract Doc Link 20111869 Disease Relevance 0.08 Pain Relevance 0.89
Additionally, BUP inhibits NBUP glucuronidation (UGT1A1, 1A3, HLMs) and vice versa (UGT1A3).
Negative_regulation (inhibits) of UGT1A3 associated with endep and buprenorphine
2) Confidence 0.42 Published 2010 Journal Int. J. Legal Med. Section Abstract Doc Link 20111869 Disease Relevance 0.09 Pain Relevance 0.90

General Comments

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