INT165989

Context Info Confidence 0.53 First Reported 2007 Last Reported 2010 Negated 4 Speculated 1 Reported most in Body Documents 4 Total Number 11 Disease Relevance 2.58 Pain Relevance 1.10

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency chondrocytes 4 cartilage 2 TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 210 97.72 Snapping jaw 56 91.52 cytokine 54 88.76 cINOD 4 86.68 Hyperalgesia 7 41.72 Pain 20 41.04 Inflammation 54 31.32 Paracetamol 3 26.64 metalloproteinase 7 5.00 Bioavailability 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 59 99.40 Knee Osteoarthritis 1 97.92 Arthropathy 31 92.88 Osteoarthritis 209 92.56 Osteoporosis 55 92.08 Temporomandibular Joint Syndrome 56 91.52 Hypercalcemia 35 86.96 Apoptosis 3 70.68 Necrosis 3 55.92 Cancer 3 55.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

OPG expression (Figure 2a) was not altered by treatment with vitamin D3.

Neg (not) Regulation (altered) of Gene_expression (expression) of OPG

1) Confidence 0.53 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.31 Pain Relevance 0.09

Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis.

Regulation (modulate) of Gene_expression (synthesis) of osteoprotegerin in cartilage associated with inflammation, knee osteoarthritis and osteoarthritis

2) Confidence 0.42 Published 2010 Journal Arthritis Rheum. Section Title Doc Link 20112374 Disease Relevance 0.47 Pain Relevance 0.31

In the present study, we explored in human subchondral bone whether CS and GS or both together affect certain bone biomarkers, OPG and RANKL levels, and pro-resorptive activity.

Spec (whether) Regulation (affect) of Gene_expression (levels) of OPG

3) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 1.08 Pain Relevance 0.32

, RANKL, M-CSF, and OPG gene expression was unaffected by the presence of celecoxib.

Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of OPG gene

4) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0

Data showed that vitamin D3 had no effect on the OPG gene expression and protein levels but markedly increased RANKL and, as a result, significantly inhibited the expression ratio of OPG/RANKL.

Neg (no) Regulation (effect) of Gene_expression (expression) of OPG gene

5) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.11 Pain Relevance 0.07

As a result, OPG and RANKL expression increased with IL-1?

Regulation (with) of Gene_expression (expression) of OPG

6) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.06 Pain Relevance 0.03

Komuro et al. [4] reported that OPG expression in chondrocytes increased in response to IL-1?

Regulation (chondrocytes) of Gene_expression (expression) of OPG in chondrocytes

7) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.19 Pain Relevance 0.09

on the expression of OPG and RANKL; whereas it did not affect the IL-1?

Regulation (on) of Gene_expression (expression) of OPG

8) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0

showed the same effect for the expression of RANKL, M-CSF, and OPG for any culture period, while the control value changed in the long-term culture.

Regulation (effect) of Gene_expression (expression) of OPG

9) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0

In many previous studies on M-CSF, RANKL, and OPG expression in chondrocytes, the culture periods were brief (24?

Regulation (studies) of Gene_expression (expression) of OPG in chondrocytes

10) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.18 Pain Relevance 0.09

upregulated the expression and synthesis of RANKL; whereas OPG expression was unaffected after 4 and 24 hours.

Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of OPG

11) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.20 Pain Relevance 0.10

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