INT165990

Context Info Confidence 0.35 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency cartilage 2 TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 5 50.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 4 76.52 INFLAMMATION 2 50.00 Knee Osteoarthritis 1 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS: In patients with OA, celecoxib decreased RANKL synthesis in the cartilage, thereby increasing the OPG:RANKL ratio.

Negative_regulation (decreased) of Positive_regulation (increasing) of OPG in cartilage

1) Confidence 0.35 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20112374 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.