INT166006

Context Info Confidence 0.46 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.32 Pain Relevance 0.83

transport (Scnn1a) plasma membrane (Scnn1a)

Anatomy Link Frequency oocytes 1 Scnn1a (Mus musculus)

Pain Link Frequency Relevance Heat sodium channel 11 100.00 Action potential 3 99.90 ASIC 7 92.32 Potency 2 81.36 Multiple sclerosis 1 81.12 Pain 1 79.52 member 8 1 46.80 Serotonin 4 5.00 Central nervous system 1 5.00 midbrain 1 5.00

Disease Link Frequency Relevance Heat Demyelinating Disease 1 81.12 Stroke 1 80.20 Pain 1 79.52 Neurological Disease 1 79.00 Targeted Disruption 3 5.00 Salivary Gland Disease 2 5.00 Polycystic Kidney Disease 2 5.00 Aids-related Complex 1 5.00 Dysgeusia 1 5.00 Body Weight 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These four compounds (100 microM) failed to block ENaC channels expressed in oocytes.

Gene_expression (expressed) of ENaC in oocytes

1) Confidence 0.46 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20114056 Disease Relevance 0.32 Pain Relevance 0.46

A third study has demonstrated that AS cells can generate action potentials and express ENaC subunits, suggesting that AS cells may be taste cells distinct from Type I cells without action potentials [56].

Gene_expression (express) of ENaC associated with action potential and sodium channel

2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0.36

General Comments

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