INT166013

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.15
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA)
enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)
Anatomy Link Frequency
platelet 2
NFKBIA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 174 99.36 Very High Very High Very High
aspirin 11 98.72 Very High Very High Very High
corticosteroid 112 94.00 High High
COX-2 inhibitor 2 78.92 Quite High
cINOD 6 77.08 Quite High
cytokine 26 59.40 Quite High
Inflammatory response 114 33.36 Quite Low
Inflammatory stimuli 70 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 308 99.36 Very High Very High Very High
Apoptosis 4 92.28 High High
Squamous Cell Carcinoma 3 81.20 Quite High
Cancer 3 74.68 Quite High
Disease 12 58.68 Quite High
Systemic Inflammatory Response Syndrome 8 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Bacterial Infection 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dynamics of the gene transcript of IKBa (mRNA,IKBa), (2c), are characterized by a zero order production rate (Kin,IkBa) and a first order degradation rate (Kout,IkBa) which is stimulated by NFkB [36].
Positive_regulation (stimulated) of Gene_expression (production) of IkBa
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.18 Pain Relevance 0.09
IkBa, IL-10; (ii) or increased expression of an inhibitor to phospholipase A2 (annexin I) which subsequently leads to reduced formation of both arachidonic acid and platelet-activating factor as well as (ii) a disruption of the basal transcriptional machinery that inhibits the transcriptional activity of NFkB.
Positive_regulation (increased) of Gene_expression (expression) of IkBa in platelet
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.34 Pain Relevance 0.47
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Positive_regulation (activation) of Gene_expression (proteolysis) of IkappaB-alpha associated with aspirin
3) Confidence 0.05 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox