INT166016

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.05
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
Anatomy Link Frequency
cleavage 2
fibroblasts 1
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 40 99.20 Very High Very High Very High
aspirin 11 97.72 Very High Very High Very High
Osteoarthritis 21 90.44 High High
Arthritis 27 73.36 Quite High
COX-2 inhibitor 3 60.20 Quite High
cINOD 4 58.36 Quite High
antagonist 1 55.28 Quite High
Inflammatory mediators 3 48.56 Quite Low
palliative 2 38.08 Quite Low
Kinase C 2 20.44 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 132 99.32 Very High Very High Very High
Rheumatoid Arthritis 40 99.20 Very High Very High Very High
Osteoarthritis 21 90.44 High High
Death 17 88.76 High High
Cancer 39 83.60 Quite High
Multiple Myeloma 3 81.60 Quite High
Lung Cancer 3 79.84 Quite High
Metastasis 2 77.20 Quite High
Colon Cancer 2 76.08 Quite High
Squamous Cell Carcinoma 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase-dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB.
Protein_catabolism (proteolysis) of Mcl-1 associated with aspirin and apoptosis
1) Confidence 0.76 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.59 Pain Relevance 0.56
Degradation of Mcl-1, e.g. by caspase-3, -8 or granzyme B-mediated cleavage [12], enables proapoptotic Bcl-2 proteins to initiate mitochondrial acitivation.
Protein_catabolism (Degradation) of Mcl-1 in cleavage
2) Confidence 0.63 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.30 Pain Relevance 0
Interestingly, Mcl-1 degradation by EGCG sensitized RA synovial fibroblasts to TNF?
Protein_catabolism (degradation) of Mcl-1 in fibroblasts associated with rheumatoid arthritis
3) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.85 Pain Relevance 0.59
Expression of p53, p21CIP1 & Mcl-1 and PARP cleavage were next evaluated by Western blotting (Figure 2).
Protein_catabolism (cleavage) of Mcl-1 in cleavage
4) Confidence 0.03 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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