INT166021

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 62.97
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
Anatomy Link Frequency
heart 4
Myeloid cell 2
EAT 1
frontal cortex 1
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 12 98.56 Very High Very High Very High
Potency 3 98.48 Very High Very High Very High
ischemia 27 97.40 Very High Very High Very High
imagery 79 97.16 Very High Very High Very High
Inflammation 141 85.84 High High
palliative 9 73.24 Quite High
COX-2 inhibitor 2 61.88 Quite High
antagonist 15 61.00 Quite High
Inflammatory mediators 22 60.28 Quite High
cINOD 4 60.04 Quite High
Disease Link Frequency Relevance Heat
Obesity 3502 100.00 Very High Very High Very High
Apoptosis 826 100.00 Very High Very High Very High
Leukemia 29 100.00 Very High Very High Very High
Metabolic Syndrome 601 99.86 Very High Very High Very High
Urological Neuroanatomy 6 99.80 Very High Very High Very High
Mycobacterial Infection 144 99.64 Very High Very High Very High
Malignant Neoplastic Disease 22 99.52 Very High Very High Very High
Infection 96 99.46 Very High Very High Very High
Carcinoma 379 99.44 Very High Very High Very High
Coronary Artery Disease 583 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study demonstrates that targeting of Mcl-1 by siRNA sensitizes HCC cell lines to chemotherapy and molecularly targeted therapy.
Positive_regulation (targeting) of Mcl-1 associated with carcinoma
1) Confidence 0.67 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.77 Pain Relevance 0
By in silico analysis, Mott et al. identified a putative target site in the Mcl1 mRNA and found that miR-29b was downregulated in malignant cells, consistent with Mcl1 protein upregulation.
Positive_regulation (upregulation) of Mcl1 associated with malignant neoplastic disease
2) Confidence 0.63 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.94 Pain Relevance 0
Our study also observed a constant and parallel increase of left ventricular mass and EAT in patients with severe heart failure.
Positive_regulation (increase) of EAT in heart associated with obesity and myocardial infarction
3) Confidence 0.50 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.48 Pain Relevance 0.05
Increased EAT could serve as a scavenger of excess fatty free acids which interfere with the generation and propagation of the contractile circle of the heart, may cause ventricular arrhythmias and are supposed to alter cardiac repolarization [15,16].
Positive_regulation (Increased) of EAT in heart associated with obesity
4) Confidence 0.50 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.17 Pain Relevance 0.03
The median EAT thickness was significantly increased in patients with CAD compared to patients without CAD (1.7 vs. 3.5 mm, p < 0.001).
Positive_regulation (increased) of EAT associated with coronary artery disease and obesity
5) Confidence 0.50 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 3.12 Pain Relevance 0
The median EAT thickness was significantly increased in the high BMI group compared to that of the non-high BMI group (3.0 vs. 2.8 mm, p = 0.01).
Positive_regulation (increased) of EAT associated with obesity
6) Confidence 0.50 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 2.47 Pain Relevance 0
The median EAT thickness was significantly increased in patients with MS compared to those without MS (3.3 vs. 2.0 mm, p < 0.001).
Positive_regulation (increased) of EAT associated with obesity and metabolic syndrome
7) Confidence 0.50 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 2.79 Pain Relevance 0
In the non-high BMI group, the median EAT thickness was significantly increased in patients with MS compared to those without MS (3.5 vs. 1.9 mm, p < 0.001, Figure 2).
Positive_regulation (increased) of EAT associated with obesity and metabolic syndrome
8) Confidence 0.50 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 2.85 Pain Relevance 0
In the high BMI group, the median EAT thickness was not significantly increased in patients with MS compared to those without MS (3.0 vs. 2.5 mm, p = 0.813, Figure 2).
Neg (not) Positive_regulation (increased) of EAT associated with obesity and metabolic syndrome
9) Confidence 0.50 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 2.81 Pain Relevance 0
No sensitizing effect of Mcl-1 knockdown in HCC cells was observed for the treatment with JNK1 and Src kinase inhibitors.
Neg (No) Positive_regulation (effect) of Mcl-1 associated with carcinoma
10) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.26 Pain Relevance 0
Myeloid cell leukemia-1 (Mcl-1) is an anti-apoptotic member of the Bcl-2 family, originally identified as an early induction gene during differentiation of myeloid leukemia cells [6].
Positive_regulation (induction) of Myeloid cell leukemia-1 in Myeloid cell associated with leukemia and apoptosis
11) Confidence 0.45 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.27 Pain Relevance 0.07
Myeloid cell leukemia-1 (Mcl-1) is an anti-apoptotic member of the Bcl-2 family, originally identified as an early induction gene during differentiation of myeloid leukemia cells [6].
Positive_regulation (induction) of Mcl-1 in Myeloid cell associated with leukemia and apoptosis
12) Confidence 0.45 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.26 Pain Relevance 0.07
For example, the up-regulation of miR-34a and miR-195 was associated with a down-regulation of BCL2 and SGK1 protein levels, respectively; whereas the down-regulation of miR-193b, miR-221, miR-222 and miR-7 was associated with an up-regulation of MCL1, BCL2L11 (Bim), CDN1B (p 27) and VDAC1 protein levels, respectively (Figure 9A).
Positive_regulation (up-regulation) of MCL1
13) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.42 Pain Relevance 0
Like in healthy controls an increase in left ventricular mass also leads to an augmentation of the EAT mass in patients with CHF, however, the EAT mass/LV-EDM ratio is significantly lower compared to healthy controls.
Positive_regulation (augmentation) of EAT associated with heart rate under development and obesity
14) Confidence 0.36 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.57 Pain Relevance 0.04
However, indexed EAT did not correlate with RV-EDD, which was due to the predominantly left ventricular heart failure.
Positive_regulation (indexed) of EAT in heart associated with obesity and myocardial infarction
15) Confidence 0.36 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.68 Pain Relevance 0
The second possible explanation for the weak correlation between the EAT thickness and presence of MS and CAD in the high BMI group, might be the different proportion of the EAT to total amount of VAT according to BMI.
Positive_regulation (proportion) of EAT associated with coronary artery disease, obesity and metabolic syndrome
16) Confidence 0.36 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 3.89 Pain Relevance 0.30
These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase-dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB.
Positive_regulation (activation) of Mcl-1 associated with aspirin and apoptosis
17) Confidence 0.36 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.60 Pain Relevance 0.57
An increase in LVM is significantly related to an increase in EAT in both patients with CHF and controls.
Positive_regulation (increase) of EAT associated with heart rate under development and obesity
18) Confidence 0.34 Published 2010 Journal J Cardiovasc Magn Reson Section Abstract Doc Link PMC2914772 Disease Relevance 2.12 Pain Relevance 0
An increase in LVM is significantly related to an increase in EAT in both patients with CHF and controls.
Positive_regulation (increase) of EAT associated with heart rate under development and obesity
19) Confidence 0.34 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.61 Pain Relevance 0
As illustrated on Figure 2A there is a parallel and correlated increase in indexed EAT mass and indexed LV-EDM in patients with CHF as well as in healthy controls.
Positive_regulation (increase) of EAT associated with heart rate under development and obesity
20) Confidence 0.34 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.88 Pain Relevance 0

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