INT166022

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.17
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 22 97.72 Very High Very High Very High
COX-2 inhibitor 4 60.20 Quite High
cINOD 4 58.36 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 8 98.08 Very High Very High Very High
Squamous Cell Carcinoma 6 75.00 Quite High
Cancer 6 55.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase-dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB.
Positive_regulation (inactivation) of Protein_catabolism (proteolysis) of Mcl-1 associated with aspirin and apoptosis
1) Confidence 0.39 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.59 Pain Relevance 0.56
These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase-dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB.
Positive_regulation (activation) of Protein_catabolism (proteolysis) of Mcl-1 associated with aspirin and apoptosis
2) Confidence 0.39 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.59 Pain Relevance 0.56

General Comments

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