INT16609

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Context Info
Confidence 0.40
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.65
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (FFAR1) plasma membrane (FFAR1) signal transducer activity (FFAR1)
Anatomy Link Frequency
brain 1
adipose tissue 1
FFAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 3 97.96 Very High Very High Very High
cva 58 90.56 High High
antagonist 4 84.04 Quite High
Glutamate 4 83.60 Quite High
Clonidine 3 83.00 Quite High
adenocard 4 79.80 Quite High
Inflammation 13 75.00 Quite High
TRP channel 1 62.44 Quite High
cINOD 1 54.80 Quite High
Neuropeptide 7 33.88 Quite Low
Disease Link Frequency Relevance Heat
Obesity 3 99.16 Very High Very High Very High
Stress 2 98.44 Very High Very High Very High
Hypoxia 10 97.44 Very High Very High Very High
Sprains And Strains 14 92.16 High High
Fat Embolism 57 90.56 High High
Cerebral Hypoxia 3 89.84 High High
Disorder Of Lipid Metabolism 12 85.20 High High
INFLAMMATION 14 75.00 Quite High
Adult Respiratory Distress Syndrome 3 73.84 Quite High
Sickle Cell Anemia 1 71.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rate of FFA release is high within the first minute and continues to increase moderately hereafter.
Localization (release) of FFA
1) Confidence 0.40 Published 1991 Journal Mol. Chem. Neuropathol. Section Abstract Doc Link 1839655 Disease Relevance 0.24 Pain Relevance 0.03
The data also indicate that the fight and flight reaction is dissociated from the events that lead to FFA release, and may involve the stimulation of glutaminergic NMDA receptors.
Localization (release) of FFA associated with nmda receptor
2) Confidence 0.40 Published 1991 Journal Mol. Chem. Neuropathol. Section Abstract Doc Link 1839655 Disease Relevance 0.29 Pain Relevance 0.26
The release of FFA can be inhibited partly by CNS depressants like N6-cyclopentyladenosine, pentobarbital, ethanol, or 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3(2H)-one (THIP).
Localization (release) of FFA
3) Confidence 0.40 Published 1991 Journal Mol. Chem. Neuropathol. Section Abstract Doc Link 1839655 Disease Relevance 0.24 Pain Relevance 0.15
Within these potential new subfamilies, GPR41-43, GPR81 and HM74 are more closely related to each other than to GPR40 (for GPR41-43) and GPRV (for GPR81 and HM74).
Localization (related) of GPR40
4) Confidence 0.36 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0
Like FCCP, FFA released Ca2+ from isolated brain mitochondria and indirectly modulates store-operated Ca2+ channels.
Localization (released) of FFA in brain
5) Confidence 0.04 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19233217 Disease Relevance 0.13 Pain Relevance 0.12
The biochemical theory implicates free fatty acid (FFA), proposing that local hydrolysis of a triglyceride emboli by intrapulmonary lipase, together with the excessive mobilization of FFA from the peripheral adipose tissue by stress hormones, results in toxic pulmonary concentrations of these acids (5).
Localization (mobilization) of FFA in adipose tissue associated with stress and obesity
6) Confidence 0.01 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526389 Disease Relevance 1.34 Pain Relevance 0.25
Quantification of the reaction products by liquid scintillation counting revealed that FFA release in Yju3p-deficient LD preparations was decreased by 40%.
Localization (release) of FFA
7) Confidence 0.01 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0.25 Pain Relevance 0
CFTR knockdown cells displayed a 4-fold increase in the amount of FFA exported to the basolateral medium whereas no changes were recorded in the cellular amount of FFA (Figure 4).
Localization (exported) of FFA
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.17 Pain Relevance 0

General Comments

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